离子迁移谱技术用于直接液体进样痕量氨基酸检测

本文介绍了以电晕放电为电离源的离子迁移谱法分析液体样品的能力。采用液相直接进样技术检测亮氨酸、苯丙氨酸、丝氨酸和甘氨酸等氨基酸。给出了这些氨基酸的正离子迁移率谱。

INTRODUCTION
Amino acids are the building blocks of proteins and they are essential for many life processes. Their most important tasks include optimal transport and storage of all nutrients. A majority of diseases can be traced back to metabolic disturbances linked with amino acids. These are the reasons why it is important to have an analytical instrument for qualitative and quantitative analysis of amino acids [1]. Ion Mobility Spectrometry (IMS) is an analytical technique based on the movement of ions of a gaseous sample in a homogeneous electric field and drift gases which is determined by the size, mass, charge and shape of the ions [2-4].

简介
氨基酸是蛋白质的组成部分，在许多生命过程中都是必不可少的。它们最重要的任务包括所有营养物质的最佳运输和储存。大多数疾病可追溯到与氨基酸有关的代谢紊乱。这就是为什么有一个分析仪器对氨基酸进行定性和定量分析的重要性[1]。离子迁移光谱法（IMS）是一种基于均匀电场和漂移气体中离子运动的分析技术，该技术由质子的大小、质量、电荷和形状决定[2-4]。

In this work we will present a new technique suitable for direct liquid samples (DLS) analysis. This new technique allows direct liquid sampling into the ion mobility spectrometer without using methanol or other special solutions. This allows to analyse biological samples in their natural conditions. In addition, DLS is a technique which allows regulation of the flow of the sample during the measurement.

在这项工作中，我们将提出一种适用于直接液体样品（DLS）分析的新技术。这项新技术允许直接液体取样进入离子迁移谱仪，而不使用甲醇或其他特殊溶液。这样就可以在自然条件下分析生物样品。此外，DLS是一种允许在测量过程中调节样品流量的技术