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Recombinant Human Progesterone Receptor

供货周期：一周

品牌：

规格： 2μg

货号： PRO-535

CAS号：

报价： ¥2450

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产品介绍

Synonyms	Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3.
Introduction	PGR belongs to the steroid receptor superfamily. PGR is located on chromosome 11q22. The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. The progesterone receptor (PgR) is an estrogen-regulated protein. PGR mediates the physiological effects of progesterone, which plays a fundamental role in reproductive events associated with establishing and maintaining pregnancy. PGR uses 2 distinct promotors and translation start sites in the first exon to produce 2 isoforms, A & B, which differ in their molecular weight (isoform A has 165 additional amino acids at the N-terminus). The progesterone receptor has an amino and a carboxyl terminal, the regulatory domain between them, a DNA binding domain, the hinge section, and the hormone binding domain. If no hormone is bound the carboxyl terminal inhibits transcription. Binding to a hormone stimulates a structural change which eliminates the inhibitory action. Following the progesterone binding to the receptor, restructuring with dimerization begins and the complex enters the nucleus where it binds to DNA. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
Description	Progesterone Receptor Human Recombinant (a.a. 412-562) expressed in E.coli, shows a 43 kDa SDS-PAGE (including GST tag). The PGR is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered clear solution.
Formulation	PGR in 50mM Tris-HCl, pH7.5, 10mM L-glutathione (reduced).
Stability	Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Applications	• ELISA • Inhibition Assays • Western Blotting.
Usage	Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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上海顺元生物科技有限公司

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信用代码

310116002748169

成立日期

2012-11-29

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上海顺元生物科技有限公司

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上海市七莘路2465号

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Recombinant Human Progesterone Receptor 由上海顺元生物科技有限公司为您提供，货号PRO-535，规格：2μg，CAS号：，如您想了解更多关于Recombinant Human Progesterone Receptor 价格、Recombinant Human Progesterone Receptor 结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human Progesterone Receptor 外，还可为您提供豚鼠胰淀粉酶α2A(AMY2A)ELISA Kit、猴脂多糖结合蛋白(LBP)ELISA kit、Human Placenta-specific gene 8 protein(PLAC8) ELISA kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，顺元生物客户服务电话，售前、售后均可联系。

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Recombinant Human Progesterone Receptor

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