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当前位置：顺元生物 > 蛋白质/多肽 > Recombinant Human D4-GDI

Recombinant Human D4-GDI

供货周期： 7天

品牌：

型号： 2μg

货号： PRO-296

报价： ¥2450

产品介绍

Introduction	D4-GDI belongs to the family of Rho-GDIs or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of RhoGDI-1, D4 GDI/RhoGDI-2 and RhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. D4-GDI is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas-mediated apoptosis. D4-GDI is expressed only in hematopoietic tissues, mainly in B and T cells, unlike RhoGDI which is expressed ubiquitously. D4-GDI plays a role in the regulation of lymphocyte activation, survival, and responsiveness. Expression of D4-GDI is also observed in cells of nonhematopoietic neoplasms, including ovarian and bladder cancer cells, suggestive of D4-GDI’s role in progression of human tumors. D4-GDI is expressed in human breast cancer cells. In different human breast cancer cell lines that were studied, cell lines with high invasive activities, for example MDA-MB-231, expressed higher D4-GDI than did weakly invasive and noninvasive cell lines. Intentional disruption of D4-GDI by steadily expressing small interfering RNA (siRNA) against D4-GDI transcripts successfully blocks the motility and invasive potential of MDA-MB-231 cells in vitro. Cells deficient of D4-GDI revert to a normal breast epithelial phenotype characterized by the formation of cysts with a central lumen when grown on Matrigel. D4-GDI reduction is linked to a down-regulation of the cell surface protein ?1-integrin and a loss of cell-matrix adhesion, suggestive of D4-GDI induction of cell invasion by controlling ?1-integrin expression. The expression of ?1-integrin and invasive activities are restored once there’s restitution of D4-GDI expression to the levels found in the parental MDA-MB-231 cells. Therefore it is suggested that D4-GDI may play a significant role in the regulation of breast cancer cell invasiveness.
Description	D4-GDI Human Recombinant full length protein expressed in E.coli, shows a 54 kDa SDS-PAGE. The D4-GDI is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered clear solution.
Formulation	D4-GDI protein at 0.1mg/ml in 50mM Tris-HCl, pH7.5 and 10mM L-Glutathione (reduced).
Stability	Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Purity	Greater than 90% as determined by SDS-PAGE.
Applications	• ELISA • Inhibition Assays • Western Blotting.
Usage	Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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企业名称

上海顺元生物科技有限公司

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信用代码

310116002748169

成立日期

2012-11-29

注册资本

50

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上海顺元生物科技有限公司

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上海市七莘路2465号

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Recombinant Human D4-GDI由上海顺元生物科技有限公司为您提供，货号PRO-296，规格：2μg，CAS号：，如您想了解更多关于Recombinant Human D4-GDI价格、Recombinant Human D4-GDI结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human D4-GDI外，还可为您提供猴肿瘤坏死因子配体超家族成员13B(TNFSF13B)ELISA kit、牛脂多糖/内毒素(LPS) ELISA kit、人分泌磷蛋白2(SPP2/SPP24)ELISA kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，顺元生物客户服务电话，售前、售后均可联系。

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Recombinant Human D4-GDI

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