重组人胰岛素样生长因子-I受体(Human IGF-IR)

IGF-IR Human
Insulin-like Growth Factor-1 Receptor Human Recombinant
Catalog No. PKA-237

Synonyms:
Insulin-like growth factor 1 receptor, EC 2.7.10.1, Insulin-like growth factor I receptor, IGF-I receptor, CD221 antigen, CD221, IGFIR, JTK13, MGC18216, MGC142170, MGC142172.

Introduction:
The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembranereceptorthat is activated by IGF-1and by the related growth factor IGF-II. It belongs to the large class of tyrosine kinasereceptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscleand other target tissues.
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and Beta-subunits, which are disulfide-linked in a Beta-alpha-alpha-Beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the Beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Description:
Insulin-like growth factor 1 receptor Human Recombinant encoding 1213-1367 amino acids expressed in E.coli, shows a 43kDa band on SDS-PAGE (Including GST tag).
IGF-IR is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile filtered liquid.

Formulation:
IGF-IR protein in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.

Stability:
Store vial at -20ºC to -80ºC. When stored at the recommended temperature, this protein is stable for 12 months.
Please avoid freeze-thaw cycles.


Application And Suggested Dilutions:
• ELISA
• Inhibition Assays
• Western Blotting

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.