Recombinant Human CITED2

CITED2 Human
Cbp/p300-Interacting Transactivator 2 Human Recombinant
Catalog No. PRO-701

Synonyms:
MRG1, P35SRJ, CIT-ED2, Cbp/p300-interacting transactivator 2, MSG-related protein 1, MRG-1, CITED2.

Introduction:
CITED2 is a significant transcriptional cofactor that takes part in multiple organ development. CITED2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a negative regulator for HIF1A through its competitive binding with HIF1A to CBP/p300. CITED2 is essential for mouse fetal liver hematopoiesis and is necessary for the appropriate formation of the hyaloid vasculature and for lens morphogenesis. CITED2 is a coactivator of HNF4alpha and necessary for liver development. CITED2 is a coactivator of PPAR-alpha and both participate in signaling cascades of hypoxic response and angiogenesis.

Description:
CITED2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 278 amino acids (1-270 a.a.) and having a molecular mass of 29.5 kDa.
The CITED2 is fused to 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered colorless solution.

Formulation:
The CITED2 solution contains 20mM Tris pH-8, 1mM DTT ,0.1M NaCl & 40% glycerol.

Stability:
CITED2 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Purity:
Greater than 90.0% as determined by SDS-PAGE.

Amino acid sequence:
MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMGPPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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