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Mouse Anti Human Natural Cytotoxicity Receptor NKp46 （NKp46）

供货周期：一周

品牌：

规格： 20µg

货号： ANT-303

CAS号：

报价： ¥1820

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产品介绍

Catalogue Number

ANT-303

Synonyms

Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, hNKp46, NK-p46, NKp46, NK cell-activating receptor, Lymphocyte antigen 94 homolog, CD335 antigen, NCR1, LY94, NCRNKp46, CD335.

Type

Mouse Anti Human Monoclonal.

Introduction

A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore, NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, a

Clone

Pn1D9AT.

Immunogen

Anti-human NKp46 mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NKp46 amino acids 22-255 purified from E. coli.

Ig Subclass

Mouse IgG1 heavy chain and κ light chain.

Purification Method

NKp46 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

Protein formulation

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

Storage Procedures

For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Stability / Shelf Life

12 months at -20°C. 1 month at 4°C.

Applications

NKp46 antibody has been tested by immunofluorescent staining with flow cytometric analysis and by Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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工商信息

企业名称

上海希美化学有限公司

企业信息已认证

企业类型

信用代码

310228001203103

成立日期

2009-05-31

注册资本

经营范围

化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

联系方式

上海希美化学有限公司

公司地址

上海市松江区陆家圈路168弄113号

客服电话

Mouse Anti Human Natural Cytotoxicity Receptor NKp46 （NKp46）由上海希美化学有限公司为您提供，货号ANT-303，规格：20µg，CAS号：，如您想了解更多关于Mouse Anti Human Natural Cytotoxicity Receptor NKp46 （NKp46）价格、Mouse Anti Human Natural Cytotoxicity Receptor NKp46 （NKp46）结构式、批发、用途等信息，欢迎咨询。除供应Mouse Anti Human Natural Cytotoxicity Receptor NKp46 （NKp46）外，还可为您提供Recombinant Human CITED2、Recombinant Human 4-1BB Receptor(Human 4-1BBR)、Mouse Anti Human Caspase-2 （CASP2）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。

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Mouse Anti Human Natural Cytotoxicity Receptor NKp46 （NKp46）

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公司名称：上海希美化学有限公司

公司地址：上海市松江区陆家圈路168弄113号联系人：李保平邮编： 201619

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