核心参数
仪器种类: 倒置荧光显微镜
激发光源: 金属卤素灯
目镜: 适用标准目镜
物镜: 适用标准物镜
荧光装置: 落谢式
光源: 可适用任何光源照明
观察头: 倒置式
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RM21™: Microscope Platform for the Future |
RM21™ is a precision aligned microscope platform for epifluorescence microscopy. The RM21™ has been designed for maximum user accessibility. This feature offers users the opportunity to develop flexible configuration microscopy instruments with ease. It has been manufactured with high precision to allow easy alignment of microscopy and optical components within its three dimensional space. In addition, all posts and fixturing points are referenced to a known datum. With a robust design, precision manufacturing and assembly, the RM21™ is the ideal platform for a range of microscopy applications such as super resolution (SR) microscopy, fluorescence microscopy and TIRF. The RM21™ includes the precision platform with an axial, motorized Z axis approach suitable for lens positioning, manual or motorized XY micropositioner for sample positioning (manual version and accessories not pictured above). The Z axis has a displacement of 2 inches (50mm) with a 95nm step size. A customized platform version without XY micropositioners is available. Optional encoders can be added to motorized X, Y, and Z for accurate micropositioner displacement readouts. The RM21™ can be seamlessly integrated with the Nano-Cyte® 3D microscope stability system. The RM21™ can also interface with other Mad City Labs products like closed loop nanopositioning systems, including the Nano-LPS Series(shown above) and high speed Nano-LPQ. The Nano-OP Series and the Nano-F Series objective nanopositioners can be added on for control of focus down to the subnanometer level. The ease of integration with Mad City Labs nanopositioning and microspositioning systems provides the researcher with a flexible microscopy platform with high precision performance for the most demanding microscopy techniques. |
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在细胞水平上用共聚焦显微PIV方法研究高压积红细胞流动的近壁不稳定性
In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention. Unsteadiness is reported and quantified for the first-time in the literature using a combination of fluorescent dye labelling, time-resolved scanning confocal microscopy, and micro-particle image velocimetry (μPIV). The near-wall red blood cell (RBC) motion of physiologic high-hematocrit blood in a rectangular microchannel was investigated under pressure driven flow. Intermittent flow was associated with (1) the stretching of RBCs as they passed through RBC clusters with twisting motions; (2) external flow through local obstacles; and (3) transitionary rouleaux formations. Velocity profiles are presented for these cases. Unsteady flow clustered in local regions. Extra-cellular fluid flow generated by individual RBCs was examined using submicron fluorescent microspheres. The capabilities of confocal μPIV post-processing were verified using synthetic raw PIV data for validation. Cellular interactions and oscillating velocity profiles are presented and 3D data are made available for computational model validation.
医疗/卫生
2012/01/14
双栖小泡蛋白和N-WASP调节肌蛋白组装的相互作用动力学
Amphiphysin 1, an endocytic adaptor concentrated at synapses that couples clathrin-mediated endocytosis to dynamin-dependent fission,wasalsoshownto have a regulatory role in actindynamics. Here, we report that amphiphysin 1 interacts with N-WASP and stimulates N-WASP- and Arp2/3-dependent actin polymerization. Both the Src homology 3 and the N-BAR domains are requiredforthisstimulation.Acidicliposome-triggered,N-WASPdependent actin polymerization is strongly impaired in brain cytosol of amphiphysin 1 knock-out mice. FRET-FLIM analysis of Sertoli cells, where endogenously expressed amphiphysin 1 colocalizes with N-WASP in peripheral ruffles, confirmed the association between the two proteins in vivo. This association undergoes regulation and is enhanced by stimulating phosphatidylserine receptors on the cell surface with phosphatidylserine- containing liposomes that trigger ruffle formation. These results indicate that actin regulation is a key function of amphiphysin 1 and that such function cooperates with the endocytic adaptor role and membrane shaping/curvature sensing properties of the protein during the endocytic reaction.
医疗/卫生
2011/03/09
企业名称
北京欧兰科技发展有限公司
企业信息已认证
企业类型
信用代码
110108003886158
成立日期
2002-06-14
注册资本
50000
经营范围
技术开发、技术转让、技术咨询、技术服务;计算机技术培训;基础软件服务;应用软件服务;计算机系统服务;数据处理;计算机维修;销售计算机、软件及辅助设备、电子产品、机械设备、通讯设备、五金、交电、化工产品(不含危险化学品及一类易制毒化学品)、文化用品、体育用品、日用品。(企业依法自主选择经营项目,开展经营活动;依法须经批准的项目,经相关部门批准后依批准的内容开展经营活动;不得从事本市产业政策禁止和限制类项目的经营活动。)
北京欧兰科技发展有限公司
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