“通常合成理想的荧光染料需要合成一系列相近分子库或采取复杂的理论计算去构建染料，这一过程往往耗费着研究人员宝贵的时间金钱成本。伴随着人工智能的快速发展，机器学习的引入极大助力了科研的发展。得益于该启发，我们建立了呫吨染料数据库，通过数据分析、模型筛选，建立机器学习模型，构建了高效理性的染料设计工具，从而高效简化了合成工作量。此外，我们还引入外部染料数据、与实验室合成的染料进行模型评估，都验证了机器学习模型的良好精确性。”向飞帆表示。向飞帆师从四川大学李坤教授，上述研究已经发表在《Advanced Materials》上。

"当前测试血氧饱和度的方法有三种：脉搏血氧仪，血气分析仪和光声显微成像。脉搏血氧仪虽然可动态实时监测，但分辨率低，无法实现单根血管的血氧饱和度监测。血气分析仪准确性高，但是需要进行有创性采血监测，无法做到实时动态。光声显微成像，可以实时动态监测，分辨率高，但对深层组织的血氧饱和度成像时，准确性不够。利用我们所开发的 NIR-IIb 成像系统可以实时动态，准确的对单根血管的血氧饱和度进行可视化监测。"方治国博士表示。方博士师从国家纳米科技中心钟业腾研究员，上述研究已经发表在了《Nature Nanotechnology》上。

来自南京大学的刘震教授团队将免疫识别与等离激元拉曼检测技术相结合，创新性地发展了一种等离激元免疫夹心法（Plasmonic immunosandwich assays, PISA），成功实现了单个活细胞及活体动物内多种低拷贝数蛋白质的分析（Angewandte Chemie International Edition, 2016, 55, 13215）。

吉林大学的徐抒平教授课题组利用 SERS 技术，对比分析了不同类型乳腺癌细胞系中的3种外泌体蛋白（CD9、CD63和FAK），这3种外泌体蛋白有望用于转移性乳腺癌的早期诊断，相关文章发表在 Analytical Chemistry 上。

根据国家卫生研究所2018年公布的一项研究，对于无法手术的癌症类型，光动力学疗法有着非常广阔的应用前景，如从骨骼开始病变的骨肉瘤就是典型。

This application report shows that the ICP-AES is a suitable technique for the analysis of dialysis samples. The accuracy for the major elements can be improved by using Yttrium as internal standard. Dilution is not necessary because of the argon humidifier, sheath gas and the large internal diameter of the injector available. Because of these three features, solutions with very high level of salts can be run with ease.

This application report shows that the ICP-AES is a suitable technique for the analysis of dialysis samples. The accuracy for the major elements can be improved by using Yttrium as internal standard. Dilution is not necessary because of the argon humidifier, sheath gas and the large internal diameter of the injector available. Because of these three features, solutions with very high level of salts can be run with ease.

This application report shows that the ICP-AES is a suitable technique for the analysis of dialysis samples. The accuracy for the major elements can be improved by using Yttrium as internal standard. Dilution is not necessary because of the argon humidifier, sheath gas and the large internal diameter of the injector available. Because of these three features, solutions with very high level of salts can be run with ease.

This application report shows that the ICP-AES is a suitable technique for the analysis of dialysis samples. The accuracy for the major elements can be improved by using Yttrium as internal standard. Dilution is not necessary because of the argon humidifier, sheath gas and the large internal diameter of the injector available. Because of these three features, solutions with very high level of salts can be run with ease.

This application report shows that the ICP-AES is a suitable technique for the analysis of dialysis samples. The accuracy for the major elements can be improved by using Yttrium as internal standard. Dilution is not necessary because of the argon humidifier, sheath gas and the large internal diameter of the injector available. Because of these three features, solutions with very high level of salts can be run with ease.

在外科手术中，对肿瘤边界进行快速病理成像被认为是精准切除的关键。受激拉曼散射（SRS）成像作为一种无须标记的新型显微术，避免了传统染色处理对组织的破坏，从而有望实现在体诊断。与单色SRS相比，双色SRS由于利用组织中两种成分的化学衬度叠加成像，从而可获得与H&E标准染色类似的诊断结果。然而，当前双色SRS较低的成像速度严重制约了其在实时组织学成像中的应用。基于以上背景，复旦大学应用表面物理国家重点实验室的季敏标教授等人对双色SRS显微镜光路进行了重新设计，开发出了一种速度显著提高的光路装置，并成功实现了多种组织的实时成像。

BSA 和溶菌酶的 Zeta 电位和 pH 关系曲线与预期 相符。等电势点的滴定过程简单易行，每个实验仅需 1 小时。用于实验的塑料碳涂层电样品池没有任何降 解的迹象，仍可用于后续更多的实验。 碳涂层电的创新性使用标志着蛋白质 Zeta 电位 的测量转变为一个任何人都可以操作的简单实验。

The FLUOROLOG® system provides a quantitative assessment of tooth decay, via the FLUOROLOG®’s exclusive strong stray-light rejection, and ability to detect IR fluorescence. The FLUOROLOG®-Tau accessory provides an additional dimension of discrimination. With these data, new dental treatments and products may be assessed. Further work may lead to a quick, convenient method of tracing decay.

The fast scanning, ease of operation, and remote sampling capability of the FLUOROMAX® spectrofluorometer make it a natural choice for quantifying UV damage to hair. The data derived there from can be used for the development of treatments to revitalize damaged hair.

There are many fast optical imaging techniques available to the cell biologist which are widely used to analyse biological specimens. Emerging micro-spectroscopic techniques such as Raman microscopy open up an exciting new dimension for imaging, by combining spatial and spectroscopic information. Through the ability to investigate real cellular biochemistry it is possible to rapidly learn more about chemical processes, interactions, and behaviour, down to the single cell level.

As these examples show microspectroscopic techniques are fast becoming invaluable tools for the life sciences, allowing researchers to move closer to a complete understanding of living processes. The images resulting from techniques such as Raman or XRF are more than just pretty pictures—they provide the scientist with a new dimension of information, based upon real biochemistry and composition. The possibilities are unlimited.

ΑIIbβ3 is a key mediator in the thrombotic process and has been studied extensively. This current work reports the first Raman spectrum of the protein, and examines changes in conformation during activation. Using three common agonists (DTT, Mn(II) and EDTA), the results indicate that in each case activation is caused by reduction of disulfide links, but suggests that different disulfides are activated according to the reagent used. The histopathological correlation to these findings has yet to be determined.

Raman image has been obtained with confocal SERS microspectroscopy from a single, live K562 cancer cells treated with an anticancer drug mitoxantrone, at a concentration of 10-7 M. SERS spectra have been recorded from the inside of the cell in which silver colloidal particles have been introduced to generate the SERS effect. The potential of confocal SERS microspectroscopic imaging at the single cell level is very important for the selective analysis of drugs inside these cells.

Thanks to confocal Raman spectroscopy we have been able to investigate in vivo the epidermis chemical composition in its thickness. In depth measurements allowed us to observe modifications of the relative concentration of some components (water, proteins) depending on the depth in the skin and on its state of hydration. The use of larger numerical aperture objectives would be helpful to emphasize the in-depth variations because of the possible gain in axial resolution and therefore in-depth discrimination. Indeed, the operator could then probe in depth with a smaller step size. As a possible gain on the above measurements, the use of more powerful commercially available NIR diode lasers would yield up to ten times more laser power at the sample (60-80 mW) and would result in a tremendous improvement in terms of signal collection and integration time. ?