调谐驱动免疫细胞效力、命运和适应性的代谢因素 _其他

首页 3i讲堂调谐驱动免疫细胞效力、命运和适应性的代谢因素

调谐驱动免疫细胞效力、命运和适应性的代谢因素

其他生命科学仪器及设备

会议时间: 2019-11-15 10:00

主讲老师: David Ferrick 博士 | 副总裁

所在公司: 安捷伦Seahorse

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报告介绍主讲老师

报告介绍

Abstract:

Tune the metabolic drivers of immune cell potency, fate and fitness
The unique metabolic properties and liabilities of tumors are leading to fresh perspectives of how to intervene in this chronic, progressive disease. Much has been learned in the last decade about metabolic reprogramming in cancer. By applying this knowledge to infiltrating immune cells we are now beginning to appreciate the metabolic drivers of immune cell fitness, specifically stable mitochondrial function that can perhaps reverse exhaustion phenotypes by enhancing survival and function in hypoxic and nutritionally depleted tumor microenvironments
Agilent’s cell analysis portfolio uses label-free, time resolved technology to detect discrete changes in cell fate and behavior, providing a window into the critical functions driving cell signaling, proliferation, activation, toxicity and biosynthesis. Move beyond analyzing what your cells are, and reveal a clearer picture of what they do.

This talk will showcase purpose-built applications that enable real-time measures of immune cell function, fate and fitness. This tool bench provides the capability to measure, engineer and control immune cell function, thus enabling translational researchers and developers to achieve the necessary level of therapeutic potency and safety.

开发过程中各阶段的测量工具：

– 利用活细胞成像技术进行实时细胞杀伤的动态分析
– 免疫细胞命运和适应性的动态分析

– 采用流式细胞仪进行多参数免疫表型分析
– 稳定的靶标基因编辑

主讲老师

David Ferrick 博士

安捷伦科技细胞分析部门副总裁

PhD., Senior Director, Agilent Cell Analysis David Ferrick began his career as a University of California professor, then entrepreneur and currently industry executive focused on life sciences tools, drug discovery and diagnostics specifically in the areas of immunology and cancer. He has commercialized many life science products into new and emerging markets based on nascent technologies and advanced several drug screening programs from target identification to preclinical testing. He has authored over 150 peer reviewed publications and 13 patents along with several book chapters. Dr. Ferrick received his Ph.D. in Microbiology and Immunology from Georgetown University in Washington D.C.

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