磷酸化蛋白磷酸酶2A（PP2Aα）抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化蛋白磷酸酶2A（PP2Aα）抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large磷酸化蛋白磷酸酶2A（PP2Aα）抗体 T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.

磷酸化蛋白磷酸酶2A（PP2Aα）抗体Also known as:

PP2A alpha (phospho Y307); p-PP2A alpha(Y307); Medium tumour antigen associated 61kDa protein; MGC786; PP2A alpha; PP2A C; PP2A PR65 alpha isoform; PP2A-alpha; PP2AA_HUMAN; PP2Ac; PP2CA; PPP2CA; Protein phosphatase 2 regulatory subunit A alpha isoform; Protein phosphatase 2, catalytic subunit, alpha isoform; Replication protein C; RP C; RP-C;磷酸化蛋白磷酸酶2A（PP2Aα）抗体 Serine threonine protein phosphatase 65 kDa; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, .

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磷酸化蛋白磷酸酶2A（PP2Aα）抗体Immunogen: KLH conjugated synthesised phosphopeptide derived from human PPP2CA around the phosphorylation site of Tyr307.

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Predicted Molecular Weight: 35kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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