磷酸化蛋白精氨酸N甲基4抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化蛋白精氨酸N甲基4抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300磷酸化蛋白精氨酸N甲基4抗体 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C.

磷酸化蛋白精氨酸N甲基4抗体Also known as:

CARM1_HUMAN; Coactivator associated arginine methyltransferase 1; Coactivator-associated arginine methyltransferase 1; Histone arginine methyltransferase CARM 1; Histone arginine methyltransferase CARM1; Histone-arginine methyltransferase CARM1; PRMT 4; Protein arginine methyltransferase; Protein arginine N methyltransferase 4; Protein arginine N-methyltransferase 4.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化蛋白精氨酸N甲基4抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human CARM1 around the phosphorylation site of Ser228.

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磷酸化蛋白精氨酸N甲基4抗体redicted Molecular Weight: 66kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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