中心体肌动蛋白γ1/增强型PI3K蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml中心体肌动蛋白γ1/增强型PI3K蛋白抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to 中心体肌动蛋白γ1/增强型PI3K蛋白抗体mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

中心体肌动蛋白γ1/增强型PI3K蛋白抗体Also known as:

Centaurin gamma 1; ANK repeat and PH domain-containing protein 2; AGAP-2; Agap2; Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; AGAP2_HUMAN; ANK repeat and PH domains 2; Arf GAP with GTP binding protein like; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; Arf GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2; Arf-GAP with GTPase; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2;中心体肌动蛋白γ1/增强型PI3K蛋白抗体 centaurin gamma1; Centaurin-gamma-1; Centg1; cnt g1; Cnt-g1; Cnt2; GGAP2; GTP binding and GTPase activating protein 2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; Nuclear GTPase PIKE; Phosphatidylinositol-3-kinase enhancer; Phosphoinositide 3 kinase enhancer; PI3K ENHANCER; PIKE.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human Centaurin gamma 1.

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中心体肌动蛋白γ1/增强型PI3K蛋白抗体Predicted Molecular Weight: 125kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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