Acclaim Trinity P2 液相色谱柱

Acclaim Trinity P2 液相色谱柱

Thermo ScientificAcclaimTrinity P2 液相色谱柱可用来分离包括一价和二价阳离子或阴离子在内的药物反离子。 这种创新性混合模式色谱柱技术可提供基于亲水作用、HILIC、阴离子交换和阳离子交换的色谱技术，从而可灵活进行方法开发。 Acclaim Trinity P2 液相色谱柱与 Acclaim Trinity P1 液相色谱柱相互补充，可同步分离多种药物成分及其反离子，从而可提供一种使用高效液相色谱进行药物反离子分析的整体解决方案。

描述

Acclaim Trinity P2 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包被有带电纳米聚合物微粒的高纯、多孔、球形硅胶颗粒组成。 这种独特的表面化学结构包含一个经过共价键合型有机层修饰的硅珠内孔区域，该有机层具有阳离子交换保留功能。 外孔表面使用阴离子交换型纳米聚合物微珠进行修饰。 这种化学结构可确保阴离子交换区和阳离子交换区在空间上实现分离。

对反离子分析具有高选择性

• 柱流失率低；与质谱（MS）和荷电气溶胶检测（CAD）技术兼容

• 水解稳定

• 高效

• 提供以下规格：粒径，3.0μm；直径，2.1mm 和 3.0mm；长度，50mm 和 100mm

关于 Acclaim Specialty HPLC 色谱柱系列
Acclaim 专用色谱柱专为满足具体应用的分离需求而进行开发、制造和测试。 这些色谱柱基于新式、独特的化学作用，可提供出色的分离度 和易用性。

• 经过测试可确保一致的分离

• 具有理想选择性，适用于分离特定的靶向分析物

• 出色的峰形

• 其性能经过测试，可确保高质量和可靠性的特定色谱分离

Acclaim Trinity P2

订货信息：

The Thermo Scientific? Acclaim? Trinity? P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.

? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening
? Retention of ionic and ionizable analytes without using ion-pairing reagents
? Compatibility with charged aerosol and mass spectrometry detection methods
? Easy to use
? Rugged packing

The Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology.  It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.

NSH Chromatographic Features

• Multiple retention mechanisms including HILIC, anion-exchange, and cation-exchange

• Adjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solvent

• Ideal selectivity for simultaneous separation of basic, neutral, and acidic analytes

• Separation of hydrophilic ionic and ionizable analytes without ion-pairing reagents

Separation of 12 common pharmaceutical counterions (both anions and cations) in less than 15 minutes using the Trinity P2 column.

Separation of a hydrophilic drug and counterion under HILIC conditions.

Data Sheets
	Thermo Scientific Acclaim Trinity P2 Columns Ideal Solution for Pharmaceutical Counterion Analysis

Manuals
	Thermo Scientific Acclaim Trinity P2 Column Product Manual
	Acclaim Trinity P2 Columns Quick Start

Application Notes
	AN 20977: Separation of Biochemical Buffering Agents Using Multi-Mode Liquid Chromatography with Charged Aerosol Detection
	Separation of Calcium, Magnesium and Counterions in a Dietary Supplement Using Multi-mode Liquid Chromatography with Charged Aerosol Detection
	API and Counterions in Adderall Using Multi-mode Liquid Chromatography with Charged Aerosol Detection
	Simultaneous Determination of Metformin and its Chloride Counterion Using Multi-Mode Liquid Chromatography with Charged Aerosol Detection
	Analysis of a Sports Beverage for Electrolytes and Sugars Using Multi-Mode Chromatography with Charged Aerosol Detection