DNASwift SAX-1S 寡核苷酸柱
将一根强阴离子交换柱与可提供超高分辨率的 Thermo Scientific™ DNASwift™ SAX-1S 寡核苷酸柱联合使用,可对寡核苷酸进行纯化。
描述
DNASwift SAX-1S 寡核苷酸柱
订货信息:
分析柱 |
DNASwift SAX-1S Monolith Column (5 x 150 mm) | 066766 |
The DNASwift™ SAX-1S is a strong anion-exchange column that
provides exceptionally high resolution for the purification of oligonucleotides.
The exceptionally high resolution provides superior purity and yields compared
to other ion-exchange or reversed-phase columns available. The DNASwift column
is ideal for therapeutic and diagnostic research, which have very high purity
and yield oligonucleotides purification requirements.
Highest resolution for oligonucleotide purification available, providing
high purity and yields.
Exceptionally high capacity provides exceptionally high yields with high
purity.
Refined selectivity, as with the DNAPac® column, for high
resolution
Compatible with high pH, solvents, and high temperatures.
The DNASwift monolith column is specifically designed to provide
exceptionally high resolution, laboratory-scale purification of oligonucleotides
by anion-exchange chromatography. The use of oligonucleotides in therapeutic and
diagnostic research is rapidly expanding. Oligonucleotides for these areas of
research must be of the highest purity. DNASwift monolith columns provide high
resolution and capacity, resulting in superior purity and yield compared to
other ion-exchange and revered-phase columns available.
The DNASwift column is a unique porous polymer monolith specifically designed
for superior performance in oligonucleotide purification. The column is a
pressure and chemically stable monolith support coated with functionalized latex
nanobeads. These latex nanobeads, beads with strong anion-exchange functional
groups, optimized for oligonucleotide separations, are similar to those of the
industry leading DNAPac columns. Similarly, the nanobeads contribute to the
DNASwift column's exceptionally high resolution and selectivity control. The
monolith, a polymer cylinder with interconnected flow through channels, provides
fast mass transfer which contributes to the exceptionally high resolution of the
DNASwift column. The porous monolith also offers low back pressure, allowing
increased flow rates with minimal loss of resolution. The combination of
functionalized latex nanobeads and monolith technology results in the DNASwift
column having very high capacity, exceptionally high resolution, and refined
selectivity control, which results in superior purity and yield of full length
oligonucleotide products purified from crude oligonucleotide samples. This makes
the DNASwift column ideal for oligonucleotide, therapeutic, and diagnostic
research. Additionally, it provides DNASwift columns with the capability to
successfully purify difficult oligonucleotide products.
DNASwift SAX-1S Specifications |
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Surface chemistry | Quaternary amine |
Column dimension | 5 × 150 mm |
Base matrix | Polymethacrylate |
Oligonucleotide binding capacity | ~20 mg/mL 20-mer |
Total binding capacity per column | ~50 mg 20-mer |
Bed height | 130 mm |
Bed volume | 2.5 mL |
pH Range | 6–12.4 for operation 2–14 for cleaning NOTE: [Salt]≥Equimolar to [NaOH]
required |
Recommended Ffow rate | 0.5–2.5 mL/min |
Maximum flow rate | 3 mL/min |
Operating column pressure | ≤ 1500 psi 10.3 MPa |
Maximum operating temperature | 85 °C |
Solvent compatibility | Most common organic solvents (e.g., CH3CN,
CH3OH) |
Product Data Sheets |
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| DNASwift
Monolith Column for Oligonucleotide Purification Data
Sheet |
Guides |
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| DNASwift
Monolithic Column for Oligonucleotide Purification Product Manual |
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