在PLoS ONE发表的这篇研究文章中,研究人员表示,他们已经发现,似乎能调节血液干细胞繁殖,并保留其干细胞样特性的关键分子码。团队开发出一种蛋白产品,可以直接给药至血液干细胞中,以鼓励这类细胞繁殖,而且在繁殖过程中并没有永久的遗传修饰。
利用干细胞来治疗骨髓移植癌症患者一直是常见的做法,主要研究人员Yosef Refaeli博士说:但是最大的挑战,是需要找到充足供应的干细胞,可以帮助患者在手术后抵抗感染。
研究人员在实验室中一直试图增加血液干细胞的数量,但大多数这些方法被所获得的初始血液干细胞或血液干细胞繁殖不足的性质所限制。根据PLOS ONE的这篇文章描述,研究人员曾从脐带血,成人骨髓或成人外周血中获取血液干细胞。现在,找到了使血液干细胞繁殖,而且在繁殖过程中并没有永久的遗传修饰的新技术。
现在的目标是将该技术从实验室移到进入到临床试验阶段。
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