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NFKBIA抗原（重组蛋白）
中文名称： NFKBIA抗原（重组蛋白）
英文名称： NFKBIA Antigen (Recombinant Protein)
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
Fusion protein corresponding to a region derived from 1-317 amino acids of human NFKBIA
技术规格
Full name: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
Synonyms: | IKBA; MAD-3; NFKBI |
Swissprot: | P25963 |
Gene Accession: | BC004983 |
Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: | Escherichia coli |
Tags: | His tag C-Terminus, GST tag N-Terminus |
Background: | This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. |
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