兔抗COP1多克隆抗体
中文名称:兔抗COP1多克隆抗体
英文名称: Anti-COP1 rabbit polyclonal antibody
别 名: COP1 E3 ubiquitin ligase; RFWD2; RNF200
相关类别: 一抗
抗 原: COP1
储 存: 冷冻(-20℃)
宿 主: Rabbit
反应种属: Human, Mouse
标记物: Unconjugate
克隆类型: rabbit polyclonal
Background: | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). |
Applications: | ELISA, IHC |
Name of antibody: | COP1 |
Immunogen: | Synthetic peptide of human COP1 |
Full name: | COP1 E3 ubiquitin ligase |
Synonyms: | RFWD2; RNF200 |
SwissProt: | Q8NHY2 |
IHC positive control: | Human liver cancer and Human thyroid cancer |
IHC Recommend dilution: | 20-100 |
企业名称
上海酶联生物科技有限公司
企业信息已认证
企业类型
有限责任公司(自然人投资或控股)
信用代码
91310112594715010G
成立日期
2012-04-18
注册资本
人民币500.0000万元整
经营范围
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