全自动脑立体定位仪

玉研仪器自主研发脑立体定位仪十四年，适用于大鼠、小鼠等实验动物，经典十字操作臂实现精准定位，精度可达10微米，特制螺纹精密螺杆，稳固不晃动实现对特定脑区的精确定位，是神经环路研究、神经系统性疾病、神经药理等领域内的重要研究设备，广泛面向全国各大科研院校,医院,高新企业,药企,医疗机构等科研单位。新一代电脑控制自动化立体定位仪，集成脑图谱，快速定位，实现实验动物脑部精确钻孔与微量注射等操作。

全自动脑立体定位仪是结合了stoelting公司经典的U型框设计，定制马达和创新性软件，是一款全新的划时代产品。通过StereoDrive软件，全自动脑立体定位仪能够通过马达和电脑控制三个轴方向上的位移 。另外软件中整合了 Paxinos 和 Watson 的《大鼠脑定位图谱》，能够更方便和更直观的进行脑立体定位。

产品特点：

操作方便、精准
· 脑立体定位仪，对于小动物的脑部手术来说，是一种可靠的，多功能的设备。
· 通过仪器的精确定位，可以确保电极、微管以及其它设备在实验过程中的精确定位。




微量注射泵模块（可选）：
· 由微型电动机来准确地控制推进和停止hamilton注射器，注射器可以方便地固定在脑立体定位仪上。
· 菜单操作简单，可以通过平台选择注射器的型号，设定注射容量、注射速度。
· 流速范围：0.01 µl/min到200 µl/min



颅骨钻模块（可选）：
· 集成式电动机和低震动的柔韧性轴，噪音低，性能可靠；
· 电动机集成化固定在支撑架上；
· 可选用手动或脚踏开关控制，颅钻最大转速每分钟10000转。




前囟监测观察器（可选）：
· 实时精确观察定位情况；
· 减少人为失误，确保手术精度；

 

motorized rat stereotaxic instruments

The Motorized Rat Stereotaxics combines the classic stereotaxic design with customized motors and state-of-the-art software. Integrated with popular stereotaxic atlases the StereoDrive software allows motorized, computer controlled stereotaxic positioning in all 3 orthogonal axes. The intuitive movement control enables unprecedented accuracy and higher throughput in all stereotaxic applications.

The Motorized Lab Standard Stereotaxic combines the classic design of our time-proven ‘U’-Frame with customized motors and state-of-the-art software.

Designed to adapt conventional stereotaxic systems, the StereoDrive software allows motorized, computer controlled stereotaxic positioning in all 3 orthogonal axes.

Integrated with Paxinos and Watson’s Rat Brain in Stereotaxic Coordinates, for either rat or mouse, the intuitive movement control enables unprecedented accuracy and higher throughput in all stereotaxic applications.

Features:

 Digital Atlas integration

 Frame representation

 Calibration of frame coordinates

 Setting of logical coordinate system (Bregma)

 Coordinates and Atlas visualization of the probe

 Advanced 3D visualization options

 Spatial Atlas representation

 Intuitive probe control

 Intuitive navigation

Axial View                       Coronal View              Sagittal View          Working View

Motorized UpgradeYour choice of two service options:

 Option 1: New Motorized Manipulator Arm and Axis StereoDrive Software
Keep your existing arm. We'll ship you a new one.

 Option 2: Conversion to Motorized Manipulator Arm and Axis StereoDrive Software
Send us your existing arm. We will convert it to motorized for you.

Motorized Lab Standard Stereotaxic Software SamplerThe StereoDrive software display is divided into the navigation section on the left and the 3D atlas view on the right side of the window.

1. Atlas View

2. Actual position of the probe (logical or physical)

3. Axial view thumbnail — indicating the movement in anterior-posterior (X-axis) or medio-lateral (Y Axis) direction

4. Coronal view thumbnail — indicating the movement in medio-lateral (Y-axis) or inferior-superior (Z Axis) direction

5. Anterior-posterior (X) drive control region

6. Medio-lateral (Y) drive control region

7. Inferior-superior (Z) drive control region

8. Actual coordinates of the probes tip

9. Editable target coordinates of the probes tip

10. Stop button

11. GoTo button

12. Set Lambda button — setup of the logical coordinate system

13. Set Bregma button — setup of the logical coordinate system

14. Tools — access to the microdrive calibration (frame coordinate system)

Motorized StereoDrive Software 
Included with Motorized Lab Standard? Stereotaxic

Axis StereoDrive Software integrates seamlessly with the precision controlled motors. Motor movement can be executed by using the keyboard arrow keys or clicking on the screen with the mouse.

The software coordinates motor movement of all 3 axes (anterior-posterior, medial-lateral, and dorsal-ventral) probe placement in relation to 3-dimensional visual representation of a rat (Paxinos & Watson, 6th Edition) or mouse (Watson, 3rd edition) Brain Atlas.

Features

 Easy calibration

 Software-driven control of stereotaxic movement

 Virtual visualization of probe location

 One micron resolution

 Download coordinates to computer for recall and/or archiving

 Angle adjustments

 Variable speed on 2-axis (dorsal-ventral)

The Motorized Lab Standard Stereotaxic combines the classic design of our time-proven ”U”-Frame with customized motors and state-of-the-art software.Designed to adapt conventional stereotaxic systems, the StereoDrive software allows motorized, computer controlled stereotaxic positioning in all 3 orthogonal axes.

Integrated with Paxinos and Watson’s Rat Brain in Stereotaxic Coordinates, the intuitive movement control enables unprecedented accuracy and higher throughput in all stereotaxic applications

Image manipulations include:

 Spatial Rotation

 Fixed Rotation

 Zooming

 Panning

参考文献：

1. Albéri, L., Lintas, A., Kretz, R., Schwaller, B., & Villa, A. E. (2013). The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons. Journal of neurophysiology, 109(11), 2827-2841.

2. Sonati, T., Reimann, R. R., Falsig, J., Baral, P. K., O’Connor, T., Hornemann, S., Aguzzi, A. (2013). The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501(7465), 102-106.

3. Ali, I., O’Brien, P., Kumar, G., Zheng, T., Jones, N. C., Pinault, D., O’Brien, T. J. (2013). Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy. PLOS ONE, 8(6), e66962.

4. Bell, L. A., Bell, K. A., & McQuiston, A. R. (2013). Synaptic Muscarinic Response Types in Hippocampal CA1 Interneurons Depend on Different Levels of Presynaptic Activity and Different Muscarinic Receptor Subtypes. Neuropharmacology.

5. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.

6. Bolzoni, F., Bączyk, M., & Jankowska, E. (2013). Subcortical effects of transcranial direct current stimulation (tDCS) in the rat. The Journal of Physiology.

7. Babaei, P., Tehrani, B. S., & Alizadeh, A. (2013). Effect of BDNF and adipose derived stem cells transplantation on cognitive deficit in Alzheimer model of rats. Journal of Behavioral and Brain Science, 3, 156-161.

8. Gilmartin, M. R., Miyawaki, H., Helmstetter, F. J., & Diba, K. (2013). Prefrontal Activity Links Nonoverlapping Events in Memory. The Journal of Neuroscience, 33(26), 10910-10914.

9. Feng, L., Sametsky, E. A., Gusev, A. G., & Uteshev, V. V. (2012). Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target. Journal of Neurophysiology, 108(7), 1884-1894.

10. Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., Van der Valk, P., Kipp, M. (2012). Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions. Glia, 60(10), 1468-1480.

11. Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Troadec, J. D. (2011). Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: A PGE2-independent mechanism.Toxicological Sciences, 124(1), 179-191.

12. Hruška-Plocháň, M., Juhas, S., Juhasova, J., Galik, J., Miyanohara, A., Marsala, M., Motlik, J. (2010). A27 Expression of the human mutant huntingtin in minipig striatum induced formation of EM48+ inclusions in the neuronal nuclei, cytoplasm and processes. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.

13. Brooks, S., Jones, L., & Dunnett, S. B. (2010). A29 Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A10.

14. Yu, L., Metzger, S., Clemens, L. E., Ehrismann, J., Ott, T., Gu, X., Nguyen, H. P. (2010). A28 Accumulation and aggregation of human mutant huntingtin and neuron atrophy in BAC-HD transgenic rat. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A9-A9.

15. Baxa, M., Juhas, S., Pavlok, A., Vodicka, P., Juhasova, J., Hruška-Plocháň, M., Motlik, J. (2010). A26 Transgenic miniature pig as an animal model for Huntington’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 81(Suppl 1), A8-A9.

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