描述: EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
别名: F1013
分子式: C18H23FN2O6
In vivo(体内研究): EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal rate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function.