公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 产品描述: 产品名称:Caspase-3/7 Inhibitor I 参考文献: 1.Lee, D.,Long, S.A.,Adams, J.L., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. The Journal of Biological Chemisty 275, 16007-16014 (2000). 2.Lee, D.,Long, S.A.,Murray, J.H., et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. Journal of Medicinal Chemistry 44, 2015-2026 (2001).
CAS号: 1110670-49-9 靶点: Caspase-3,Caspase-7 描述: Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 μM) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 μM) and in chondrocytes (44% inhibition at 10 μM and 98% inhibition at 50 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. 别名: 5-[[2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-1H-indole-2,3-dione 外观: solid 分子式: C14H16N2O5S 分子量: 324.4 纯度: ≥98% 储存/保存方法: Store at -20℃ 产品信息订购:
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