Z-IETD-FMK

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

产品描述：

产品名称：Z-IETD-FMK

描述:

Z-IETD-FMK is a specific Caspase-8 inhibitor.

别名: Caspase-8 Inhibitor；Z-IE(OMe)TD(OMe)-FMK

CAS号: 210344-98-2

靶点: Caspase-8

In vitro(体外研究): Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.

分子式: C₃₀H₄₃FN₄O₁₁

In vivo(体内研究): In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries.

分子量: 654.68

纯度: 98%

储存/保存方法: store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

可溶性/溶解性: DMSO ：84 mg/mL (128.3 mM)

产品信息订购：

产品更多信息请进入爱必信网站咨询