公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 产品描述: 产品名称:Z-DEVD-FMK 描述: Z-DEVD-FMK是一种特异性,不可逆的Caspase-3抑制剂,也能有效抑制caspase-6, caspase-7, caspase-8和caspase-10。 别名: Caspase-3 Inhibitor 参考文献: [1] Rickers A, et al. Eur J Immunol. 1998, (1), 296-304. [2] Yakovlev AG, et al. J Neurosci. 1997, 17(19), 7415-7424. [3] Wang J, et al. J Card Fail. 2000, 6(3), 243-249. [4] Meguro T, et al. Stroke. 2001, 32(2), 561-566. [5] Kanthasamy AG, et al. Free Radic Biol Med. 2006, 41(10), 1578-1589. CAS号: 210344-95-9 靶点: Caspase-3 In vitro(体外研究): Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Z-DEVD-FMK (100μM) attenuates OxyHb-induced cell detachment, reduced caspase-2 and -3 activities, abolishes OxyHb-induced DNA ladders, and prevents OxyHb-induced cleavage of PARP in cultured brain microvessel endothelial cells. Z-DEVD-FMK (100 μM) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 μM. 分子式: C30H41FN4O12 外观: White to slightly brown solid In vivo(体内研究): Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery. 分子量: 668.66 纯度: 98% 储存/保存方法: store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 可溶性/溶解性: DMSO : 100 mg/mL (149.55 mM) 产品信息订购:
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