Ac-DEVD-CHO

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产品描述：

产品名称：Ac-DEVD-CHO

描述:

Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.

别名: Caspase-3 Inhibitor I；N-Ac-Asp-Glu-Val-Asp-CHO；Acetyl-aspartyl-glutamyl-valyl-aspartal

CAS号: 169332-60-9

靶点: Caspase-3,caspase-8,caspase-7,caspase-10 ,Caspase-1

In vitro(体外研究): Ac-DEVD-CHO is a potent inhibitor of caspase-3 (Ki = 230 pM). In contrast, caspase-2 cleaves the tetrapeptide substrate poorly and is only weakly inhibited by this aldehyde (Ki = 1.7 μM). Group III caspases are broadly inhibited by Ac-DEVD-CHO with Ki values ranging from 1 to 300 nM. Inhibition of caspase-3 by Ac-DEVD-CHO in isolated working-heart rat model significantly improves post-ischemic contractile recovery of stunned myocardium, even when given after the onset of ischemia. The mechanism(s) of protection by Ac-DEVD-CHO appear to be independent of apoptosis. Troponin I cleavage was not inhibited by Ac-DEVD-CHO.

分子式: C₂₀H₃₀N₄O₁₁

外观: white powder

In vivo(体内研究): Ac-DEVD-CHO administered at the time of MI results in a 61% reduction in activated caspase-3 expression in cardiomyocytes (p. Ac-DEVD-CHO suppressed and/or delayed the progression of photoreceptor cell damage in rats and delays disease progression in rd gene-carring mice, which normally develop retinal degeneration early in life.

分子量: 502.5

纯度: >98%

储存/保存方法: store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

可溶性/溶解性: H2O : ≥ 50 mg/mL (99.51 mM)mL

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