公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 产品描述: 产品名称:Recombinant Human Mesothelin/MSLN/CAK1/MPF (C-6His) 描述: Recombinant Human Mesothelin is produced by our Mammalian expression system and the target gene encoding Leu37-Arg286 is expressed with a 6His tag at the C-terminus. 氨基酸序列: LAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQL RCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAA LACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGG PPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERVDHHHHHH 背景说明: Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy. 别名: Mesothelin, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, MSLN Accession: Q13421 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Human Cells 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 形态: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. 溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs04515 |
Recombinant Human Mesothelin/MSLN/CAK1/MPF (C-6His) |
10ug |
630.00 |
立即咨询 |
abs04515 |
Recombinant Human Mesothelin/MSLN/CAK1/MPF (C-6His) |
50ug |
1512.00 |
立即咨询 |
abs04515 |
Recombinant Human Mesothelin/MSLN/CAK1/MPF (C-6His) |
500ug |
10584.00 |
立即咨询 |
abs04515 |
Recombinant Human Mesothelin/MSLN/CAK1/MPF (C-6His) |
1mg |
14400.00 |
立即咨询 |
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