公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 产品描述: 产品名称:Recombinant Mouse TIGIT/VSIG9/VSTM3 (C-6His) 描述: Recombinant Mouse TIGIT is produced by our Mammalian expression system and the target gene encoding Gly26-Phe135 is expressed with a 6His tag at the C-terminus. 氨基酸序列: GTIDTKRNISAEEGGSVILQCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGP SLGLTFQSLTMNDTGEYFCTYHTYPGGIYKGRIFLKVQESSVAQFGGGGSHHHHHH 背景说明: T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses. 别名: T-cell immunoreceptor with Ig and ITIM domains,TIGIT,V-set and transmembrane domain-containing protein 3, VSTM3, REF: C1127 Accession: P86176 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Human Cells 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 形态: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. 溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs04479 |
Recombinant Mouse TIGIT/VSIG9/VSTM3 (C-6His) |
10ug |
798.00 |
立即咨询 |
abs04479 |
Recombinant Mouse TIGIT/VSIG9/VSTM3 (C-6His) |
50ug |
2100.00 |
立即咨询 |
abs04479 |
Recombinant Mouse TIGIT/VSIG9/VSTM3 (C-6His) |
500ug |
12936.00 |
立即咨询 |
abs04479 |
Recombinant Mouse TIGIT/VSIG9/VSTM3 (C-6His) |
1mg |
17600.00 |
立即咨询 |
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