A23187

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试剂描述：

产品名称：A23187

产品别名：Calimycin; Antibiotic A 23187

CAS号：52665-69-7

英文别名：A23187

分子量：523.62

分子式：C₂₉H₃₇N₃O₆

纯度：≥97%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

A23187 is an ionophore, highly selective for Ca²⁺, that allows for divalent cations to move across the membranes which are usually impermeable to them. The compound was originally isolated from Streptomyces chartreusensis for use as an antibiotic but has been shown to have weak in vitro antimicrobial activity against fungi and gram positive bacteria. Because of its ability to increase intracellular calcium levels of intact cells, it is used in studies of intracellular Ca²⁺ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation.

应用：A highly selective Ca²⁺ ionophore

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