脑和急性白血病胞浆蛋白抗elisa实验

脑和急性白血病胞浆蛋白抗英文名称  Anti-BAALC 

中文名称  脑和急性白血病胞浆蛋白抗体 

别    名  BAALC; BAALC_HUMAN; Brain and acute leukemia cytoplasmic; Brain and acute leukemia cytoplasmic protein; brain and acute leukemia, cytoplasmic; FLJ12015. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg  

脑和急性白血病胞浆蛋白抗抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow   

产品类型  一抗    

研究领域  肿瘤 心血管 细胞生物 神经生物学  

蛋白分子量  predicted molecular weight: 19kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human BAALC 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:50-200 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 BAALC is a 180 amino acid protein that localizes to both the membrane and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed by hematopoetic and neural cells, BAALC interacts with CaMKII and is thought to play a role in synaptic function at postsynaptic lipid rafts. BAALC may be overexpressed in acute myeloid leukemia (AML), suggesting a role in tumorigenesis. The gene encoding BAALC maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8.

Function : May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity).

Subunit : Interacts with CAMK2A (By similarity). 

Subcellular Location : Cytoplasm. Membrane. Postsynaptic lipid rafts.

Tissue Specificity : Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of 脑和急性白血病胞浆蛋白抗blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin.

Post-translational modifications : Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity).

Database links : UniProtKB/Swiss-Prot: Q8WXS3.3