丝氨酸/苏氨酸蛋白激酶2抗体

英文名称  Anti-STK2 

中文名称  丝氨酸/苏氨酸蛋白激酶2抗体 

丝氨酸/苏氨酸蛋白激酶2抗体别    名  CTCL tumor antigen se20 9; LOSK; se20 9; Serine/threonine protein kinase 2; STK2; SLK; SNF1 sucrose nonfermenting like kinase; STE20 like serine/threonine-protein kinase; STE20 related kinase; STK2; SLK_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg   

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep

产品类型  一抗    

研究领域  细胞生物 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶 细胞骨架  

蛋白分子量  predicted molecular weight: 143kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human STK2 (885-931aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

丝氨酸/苏氨酸蛋白激酶2抗体产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

丝氨酸/苏氨酸蛋白激酶2抗体产品介绍 SLK is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics.

Function : SLK is a serine/threonine protein kinase that is involved in cytoskeletal reorganization and apoptosis. SLK is a microtubule-associated protein inducing actin stress fiber disassembly, it also mediates apoptosis and it is ubiquitously expressed; highest expression is found in heart and in skeletal muscle. There are two named isoforms.

Subcellular Location : Cytoplasmic

Tissue Specificity : Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. 

Post-translational modifications : Proteolytically cleaved by caspase-3. 

Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 

Contains 1 protein kinase domain. 

Contains 1 UVR domain. 

Database links : UniProtKB/Swiss-Prot: Q9H2G2.1