英文名称 Anti-Somatostatin 28/GRIH
中文名称 生长抑素抗体
生长抑素抗体别 名 Growth hormone release inhibiting factor; SMS_HUMAN; SMST; SST; Somatostatin 28; Somatostatin28; Somatostatin-28; somatostatin SS28.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Sheep
产品类型 一抗
研究领域 神经生物学 生长因子和激素
蛋白分子量 predicted molecular weight: 13kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Somatostatin 28
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
生长抑素抗体产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008].
Function : Somatostatin inhibits the release of somatotropin.
Subcellular Location : Secreted.
Similarity : Belongs to the somatostatin family.
Database links : UniProtKB/Swiss-Prot: P61278.1
生长抑素是胰岛D细胞的一种多肽激素，主要用于胰岛细胞的功能性分类和消化道粘膜中内分泌细胞及肿瘤的研究。
生长抑素在体内分布广泛。在神经系统中，广泛存在于中枢和外周神经系统，在脑内以下丘脑正生长抑素抗体中隆起的浓度为最高。在新皮层，边缘系统下杏仁核，海马等部位也广泛存在，以皮层含量最高。在脊髓后根和三叉神经神经节内的一级神经元中，亦含生长抑素的免疫反应性物质。生长抑素广泛存在于胃肠道粘膜的“D”细胞，以胃窦和胃体最高，在肠内越往下含量越低。“D”细胞有长的胞浆突起，在幽门腺区止于G细胞和“嗜铬细胞”，在泌酸腺区止于壁细胞和其他上皮细胞。生长抑素通过旁分泌机制由突起释放到G细胞和壁细胞膜上，抑制胃泌素和HCI分泌，在胰腺内，生长抑素由胰岛“D”细胞分泌，通过血液循环对胰岛及消化道起作用，作为旁分泌调节胰岛功能。
生长抑素的生理作用为：抑制垂体生长激素、促甲状腺激素、促肾上腺皮质激素和催乳类的释放，也抑制各种胃肠激素的释放，抑制胃泌素、促胰液素、胆囊收缩素、胃动素、胰多肽、胰高血糖素、肠高血糖素等的释放。同时也抑制胃酸、胃蛋白酶、胰蛋白酶及唾液淀粉酶的分泌。
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