英文名称 Anti-Sphingomyelin Synthase 1
中文名称 鞘磷脂合成酶1抗体
鞘磷脂合成酶1抗体别 名 MOB; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Protein Mob; SGMS1; SMS 1; SMS1; TMEM23; Transmembrane protein 23; HSD36; SMS1_HUMAN; MOB.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit
产品类型 一抗
研究领域 肿瘤 细胞生物 免疫学 信号转导
蛋白分子量 predicted molecular weight: 49kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Sphingomyelin Synthase 1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
鞘磷脂合成酶1抗体产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008].
鞘磷脂合成酶1抗体Function : Sphingomyelin synthases synthesize the sphingolipid,sphingomyelin, through transfer of the phosphatidyl head group,phosphatidylcholine, on to the primary hydroxyl of ceramide. Thereaction is bidirectional depending on the respective levels of thesphingolipid and ceramide. Golgi apparatus SMS1 directly andspecifically recognizes the choline head group on the substrate,requiring two fatty chains on the choline-P donor molecule in orderto be recognized efficiently as a substrate. Major form inmacrophages. Required for cell growth in certain cell types such asHeLa cells. Suppresses BAX-mediated apoptosis and also preventscell death in response to stimuli such as hydrogen peroxide,osmotic stress, elevated temperature and exogenously suppliedsphingolipids. May protect against cell death by reversing thestress-inducible increase in levels of proapoptotic ceramide.
Subcellular Location : Golgi apparatus membrane; Multi-passmembrane protein.[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Namedisoforms=2; Name=1; IsoId=Q86VZ5-1; Sequence=Displayed; Name=2;IsoId=Q86VZ5-2; Sequence=VSP_027223, VSP_027224.
Tissue Specificity : Brain, heart, kidney, liver, muscle andstomach.
Similarity : Belongs to the sphingomyelin synthase family.
Contains 1 SAM (sterile alpha motif) domain.
Database links : UniProtKB/Swiss-Prot: Q86VZ5.2
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