BH3结构域凋亡诱导蛋白抗体

BH3结构域凋亡诱导蛋白抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

BH3结构域凋亡诱导蛋白抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

BH3结构域凋亡诱导蛋白抗体产品介绍

    Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas. 
    mol wt:21kDa 
    Other Aliases: 
    BH3 interacting domain death agonist; p22 BID; BID;) BH3-interacting domain death agonist; AltName: BH3-interacting domain death agonist p15; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID

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BH3结构域凋亡诱导蛋白抗体

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