表观抑制因子Polycomb家族成员PCGFl蛋白抗体说明书
2015-03-13 11:33
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表观抑制因子Polycomb家族成员PCGFl蛋白抗体说明书Background: PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.
Also known as: PCGF1; Nervous system Polycomb-1; NSPc1; Polycomb group RING finger protein 1; RING finger protein 68; PCGF1_RAT; RNF68.表观抑制因子Polycomb家族成员PCGFl蛋白抗体说明书
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