妊娠相关血浆蛋白A2抗体说明书
2015-03-13 10:33
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妊娠相关血浆蛋白A2抗体说明书Background: Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2.
Also known as: PAPPA 2; PAPP E; PAPP-A2; PAPP-E; PAPP2_HUMAN; PAPPA 2; PAPPA2; Pappalysin 2; Pappalysin-2; PLAC3; Pregnancy associated plasma protein A2; Pregnancy associated plasma protein E1; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1.妊娠相关血浆蛋白A2抗体说明书
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