磷酯酶Cγ2抗体

英文名称    PLCG 2    

中文名称    磷酯酶Cγ2抗体    

别    名    PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; EC 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C gamma 2; Phospholipase C, gamma 2 (phosphatidylinositol specific).    

磷酯酶Cγ2抗体         

说 明 书    0.2ml      

研究领域    肿瘤  免疫学  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    139kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PLCG 2/PLC gamma 2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 磷酯酶Cγ2抗体     

PubMed    PubMed    

产品介绍    background:
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide specific phospholipase C enzymes, C beta is regulated by heterotrimeric G protein coupled receptors, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases. The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.

Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Subunit:
Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) .

Post-translational modifications:
Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.

DISEASE:
Defects in PLCG2 are the cause of familial cold autoinflammatory syndrome type 3 (FCAS3) [MIM:614468]. An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk of autoimmune disorders.

Similarity:
Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC Y-box domain.
Contains 2 SH2 domains.
Contains 1 SH3 domain.

Gene ID:
5336

Database links:

Entrez Gene: 5336 Human

Entrez Gene: 234779 Mouse

Entrez Gene: 29337 Rat

Omim: 600220 Human

SwissProt: P16885 Human

SwissProt: Q8CIH5 Mouse

SwissProt: P24135 Rat

Unigene: 413111 Human

Unigene: 192699 Mouse

Unigene: 9751 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酯酶Cγ2抗体  

hz-6074R MIA2  黑色素瘤抑制活性蛋白2抗体

hz-6075R MTSS1  肿瘤转移抑制蛋白1

hz-6076R MTUS1/Angiotensin II Type 2 Receptor  血管紧张素Ⅱ2型受体相互作用蛋白抗体

hz-6077R NIT1  腈水解酶1抗体

hz-6078R RASSF3  Ras相关区域家族1A抗体

hz-6079R NPR2L/G21 protein  G21蛋白质抗体

hz-6080R XAB2/SYF1  XAB2蛋白抗体

hz-6081R PDGFRL  血小板源性生长因子受体β样蛋白抗体

hz-6082R PDSS2  抑癌蛋白DLP1抗体

hz-6083R PHAP1  蛋白磷酸酶2A抑制剂1抗体

hz-6084R POU6F2  转录因子RPF1抗体

hz-6085R PRKCDBP  蛋白激酶C delta结合蛋白抗体

hz-6086R Pinin  桥粒相关蛋白DRS抗体

hz-6088R RASAL1  RAS蛋白样激活剂1抗体

hz-6090R RBM5/LUCA15  肿瘤抑制基因LUCA15抗体

hz-6091R RERG  Ras相关雌激素调节生长抑制蛋白

hz-6092R RHOBTB1  Rho相关结构域BTB蛋白质1抗体

hz-6093R RIL  抑癌基因PDLIM4抗体

hz-6094R RIN1  RAS抑制蛋白1抗体

hz-6095R RND3/RHOE  Rho家族GTP酶3抗体

hz-6097R RSRC2  食道癌抑制生长蛋白抗体

hz-6098R PARG1/Rho GTPase activating protein 29  Rho GTP酶激活蛋白29抗体

hz-6099R SASH1  肿瘤抑制基因PEPE1抗体

hz-6100R SESN3  Sestrin3抗体

hz-5154R LSP1  白细胞F肌动蛋白结合蛋白抗体

hz-1016R E-cadherin/CD324  上皮钙粘附分子抗体

hz-6101R RUNX1T1/ETO  周期素D相关蛋白抗体

hz-4213R LARG  Rho的鸟嘌呤核苷酸交换因子12抗体

hz-6102R SCHIP1/IQCJ  IQCJ抗体

hz-6103R SEZ6L  癫痫样相关蛋白6抗体

hz-6104R SHPRH  组蛋白连接作用蛋白抗体

hz-6105R SIRT3  线粒体乙酰化酶3抗体

hz-6106R SLC5A8  钠碘转运体蛋白8抗体

hz-6107R HLTF  解旋酶样转录因子抗体

hz-6109R SNF5  转录调控激活蛋白SNF5抗体

hz-6110R SPARCL1/Ecm2  细胞外基质蛋白2抗体