磷酸化6磷酸果糖激酶2抗体

英文名称    Phospho-PFK2 (Ser467)    

中文名称    磷酸化6磷酸果糖激酶2抗体    

别    名    6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme; 6PF 2-K/Fru 2,6 P2ase 3; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase; iPFK 2; IPFK2; PFK/FBPase 3; PFK-2; PFK2; Renal carcinoma antigen NY REN 56; uPFK 2; PFKFB3; F263_HUMAN.    

磷酸化6磷酸果糖激酶2抗体      

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    细胞生物  免疫学  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    60kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化6磷酸果糖激酶2抗体   

PubMed    PubMed    

产品介绍    background:
6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.

Function:
Synthesis and degradation of fructose 2,6-bisphosphate.

Tissue Specificity:
Ubiquitous.

Similarity:
In the C-terminal section; belongs to the phosphoglycerate mutase family.

Gene ID:
5207

Database links:

Entrez Gene: 5207 Human

Entrez Gene: 5208 Human

Entrez Gene: 5209 Human

Entrez Gene: 5210 Human

Entrez Gene: 170768 Mouse

Entrez Gene: 18639 Mouse

Entrez Gene: 18640 Mouse

Entrez Gene: 270198 Mouse

Omim: 605319 Human

SwissProt: O60825 Human

SwissProt: P16118 Human

SwissProt: Q16875 Human

SwissProt: Q16877 Human

SwissProt: P70265 Mouse

SwissProt: P70266 Mouse

SwissProt: Q6DTY7 Mouse

Unigene: 195471 Human

Unigene: 282702 Human

Unigene: 444304 Human

Unigene: 476217 Human

Unigene: 132391 Mouse

Unigene: 249131 Mouse

Unigene: 249861 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化6磷酸果糖激酶2抗体

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