维生素K依赖的蛋白C轻链抗体

英文名称    protein C light chain    

中文名称    维生素K依赖的蛋白C轻链抗体    

别    名    Protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; PROC; PROC1; Vitamin K dependent protein C precursor; APC; EC 3.4.21.69; PC; proC; PROC_HUMAN; Protein C (inactivator of coagulation factors Va and VIIIa); Vitamin K dependent protein C; Vitamin K-dependent protein C; Vitamin K-dependent protein C light chain.    

维生素K依赖的蛋白C轻链抗体 

说 明 书    0.2ml      

研究领域    心血管  细胞生物  免疫学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    17/46kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Vitamin K-dependent protein C light chain    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

维生素K依赖的蛋白C轻链抗体产品介绍    background:
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].

Function:
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.

Subunit:
Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.

Tissue Specificity:
Plasma; synthesized in the liver.

Post-translational modifications:
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium. 
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans. 
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. 
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.

DISEASE:
Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3) [MIM:176860]. A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. 
Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4) [MIM:612304]. A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.

Similarity:
Belongs to the peptidase S1 family. 
Contains 2 EGF-like domains. 
Contains 1 Gla (gamma-carboxy-glutamate) domain. 
Contains 1 peptidase S1 domain.

Gene ID:
5624

Database links:

Entrez Gene: 5624 Human

Omim: 612283 Human

SwissProt: P04070 Human

Unigene: 224698 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

维生素K依赖的蛋白C轻链抗体

hz-0045PAT (Angiotenogen)  血管紧张素原（抗原）

hz-0526P5-LOX (5-lipoxygenase)  5-脂氧合酶抗原

hz-0733P-HRPADAMTS7 peptide/HRP  辣根过氧化物酶标记整合素样金属蛋白酶与凝血酶1型-7抗原

hz-0167PApo-E (Apolipoprotein E)  载脂蛋白E（抗原）

hz-2164PrhzOG 1-125 protein  重组髓鞘少树突胶质细胞糖蛋白1-125

hz-0245PIKI3 family protein  

hz-0317PILK-1 (Integrin-linked protein kinase 1)  整合素连接激酶-1

hz-0114PAromatase  芳香化酶（抗原）

hz-2337PSP-C peptide  肺表面活性蛋白C抗原

hz-2353PMast Cell Chymase  肥大细胞类糜蛋白酶1

hz-2373PCeruloplasmin peptide  铜蓝蛋白抗原

hz-2394PCKLF1  趋化素样蛋白

hz-0055PART(Arthzin)(抗原)  

hz-1510PAATK peptide  细胞凋亡关联酪氨酸激酶抗原

hz-0261PAQP-2 (aquaporin Protein-2)  水通道蛋白-2（抗原）

hz-1627PABCA1(ATP binding cassette transporter A1)  腺苷三磷酸结合盒转运体A1抗原

hz-2535PTFPI/LACI  组织因子途径抑制剂

hz-2540PGLUT12  葡萄糖转运蛋白12

hz-2558PEGFRvIII  表皮生长因子受体III型突变体抗原

hz-2570PCD26  CD26抗原

hz-1231PABCG1 peptide  三磷酸腺苷结合盒亚家族G1抗原

hz-2804PCardiac Troponin T  心肌特异性肌钙蛋白T

hz-0164PBACE( ASP2 )   β分泌酶（抗原）

hz-0583PABL1(v-abl Abelson murine leukhzia viral oncogene homolog 1)  ABL1抗原

hz-2940PFUCA1/Alpha L fucosidase I peptide  α-L岩藻糖苷酶抗原

hz-0295P-AF647Rabbit IgG/Alexa Fluor 647  Alexa Fluor 647标记兔IgG(细胞流式同型对照)

hz-0275PBassoon(BSN)  

hz-0127PBax peptide  Bax（多肽抗原）

hz-0409P-FIThzLeptin peptide/FITC  荧光素FITC标记瘦素抗原

hz-0032PBcl-2(抗原)  Bcl-2（多肽抗原）

hz-0248PBDNF (Brain-derived Neurotrophin factor)  脑源神经营养因子(脑衍化神经营养因子)（多肽片断抗原）

hz-2249PACA11 peptide  拟南芥ACA11蛋白多肽抗原

hz-2247PAHA3 peptide  植物蛋白AHA3抗原（拟南芥）

hz-0217PbFGF  碱性成纤维细胞生长因子（多肽抗原）

hz-1004PACE2(Angiotensin converting enzyme 2)  血管紧张素转换酶2抗原

hz-0044PBNP  脑钠素（多肽抗原）