垂体同源盒蛋白1抗体

英文名称    PITX-1    

中文名称    垂体同源盒蛋白1抗体    

别    名    BFT; CCF; Hindlimb expressed homeobox protein backfoot; Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; LBNBG; Paired like homeodomain 1; Paired like homeodomain transcription factor 1; Paired-like homeodomain transcription factor 1; Pituitary homeo box 1; Pituitary homeobox 1; Pituitary otx related factor; Pitx1; PITX1_HUMAN; POTX; PTX1.    

垂体同源盒蛋白1抗体       

说 明 书    0.1ml  0.2ml      

研究领域    发育生物学  信号转导  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PITX-1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

垂体同源盒蛋白1抗体产品介绍    background:
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]

Function:
May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.

Subcellular Location:
Nucleus.

DISEASE:
Defects in PITX1 are a cause of congenital clubfoot (CCF) [MIM:119800]; also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait.

Similarity:
Belongs to the paired homeobox family. Bicoid subfamily.
Contains 1 homeobox DNA-binding domain.

Gene ID:
5307

Database links:

Entrez Gene: 5307 Human

Entrez Gene: 374201 Chicken

Entrez Gene: 18740 Mouse

Entrez Gene: 113983 Rat

Omim: 602149 Human

SwissProt: P56673 Chicken

SwissProt: P78337 Human

SwissProt: P70314 Mouse

SwissProt: Q99NA7 Rat

Unigene: 84136 Human

Unigene: 135195 Mouse

Unigene: 74248 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

垂体同源盒蛋白1抗体

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hz-0777R-AF555 Rabbit Anti-Mink IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗水貂IgG

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hz-0777R-FIThz Rabbit Anti-Mink IgG/FITC  FITC标记的兔抗水貂IgG

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hz-0297D-FIThz Donkey Anti-human IgG/FITC  FITC标记的驴抗人IgG

hz-0297D-hzy3 Donkey Anti-human IgG/Cy3  Cy3标记的驴抗人IgG

hz-0297D-hzy5 Donkey Anti-human IgG/Cy5  Cy5标记的驴抗人IgG

hz-0297D-hzy5.5 Donkey Anti-human IgG/Cy5.5  Cy5.5标记的驴抗人IgG

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hz-0297D-APhz Donkey Anti-human IgG/APC  APC标记的驴抗人IgG

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hz-0297D-AF488 Donkey Anti-human IgG/Alexa Fluor 488  Alexa Fluor 488标记的驴抗人IgG

hz-0297D-AF555 Donkey Anti-human IgG/Alexa Fluor 555  Alexa Fluor 555标记的驴抗人IgG

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