磷脂酰肌醇激酶催化亚单位D抗体

英文名称    PI3 Kinase p110 delta    

中文名称    磷脂酰肌醇激酶催化亚单位D抗体    

别    名    p110D; p110delta; Phosphatidylinositol 3 kinase catalytic delta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform; Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform; Phosphoinositide 3 kinase B; Phosphoinositide 3 kinase C; Phosphoinositide 3 kinase catalytic delta polypeptide; PI3 kinase p110 subunit delta; PI3K; PIK3CD; PK3CD; PtdIns 3 kinase p110; PI 3 Kinase p110 delta; PK3CD_HUMAN; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta.    

磷脂酰肌醇激酶催化亚单位D抗体      

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  信号转导  转录调节因子  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    115kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PI3 Kinase p110 delta    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷脂酰肌醇激酶催化亚单位D抗体    产品介绍    Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.

Subunit:
Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS. Interacts with HRAS.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.

Post-translational modifications:
Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.

Similarity:
Belongs to the PI3/PI4-kinase family. 
Contains 1 C2 PI3K-type domain. 
Contains 1 PI3K-ABD domain. 
Contains 1 PI3K-RBD domain. 
Contains 1 PI3K/PI4K domain. 
Contains 1 PIK helical domain.

Gene ID:
5293

Database links:

Entrez Gene: 5293 Human

Entrez Gene: 18707 Mouse

Entrez Gene: 366508 Rat

Omim: 602839 Human

SwissProt: O00329 Human

SwissProt: O35904 Mouse

Unigene: 518451 Human

Unigene: 229108 Mouse

Unigene: 11530 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷脂酰肌醇激酶催化亚单位D抗体    

hz-0358M-APhz Mouse Anti-Guinea pig IgG/APC  APC标记的小鼠抗豚鼠IgG

hz-0358M-AF350 Mouse Anti-Guinea pig IgG/Alexa Fluor 350  Alexa Fluor 350标记的小鼠抗豚鼠IgG

hz-0358M-AF488 Mouse Anti-Guinea pig IgG/Alexa Fluor 488  Alexa Fluor 488标记的小鼠抗豚鼠IgG

hz-0358M-AF555 Mouse Anti-Guinea pig IgG/Alexa Fluor 555  Alexa Fluor 555标记的小鼠抗豚鼠IgG

hz-0358M-AF647 Mouse Anti-Guinea pig IgG/Alexa Fluor 647  Alexa Fluor 647标记的小鼠抗豚鼠IgG

hz-0358M-PE-hzy5.5 Mouse Anti-Guinea pig IgG/PE-Cy5.5  PE-Cy5.5标记的小鼠抗豚鼠IgG

hz-0358M-PE-hzy7 Mouse Anti-Guinea pig IgG/PE-Cy7  PE-Cy7标记的小鼠抗豚鼠IgG

hz-0312R-hzy3 Rabbit Anti-Avidin/Cy3  Cy3标记的兔抗亲和素

hz-0312R-hzy5 Rabbit Anti-Avidin/Cy5  Cy5标记的兔抗亲和素

hz-0312R-hzy5.5 Rabbit Anti-Avidin/Cy5.5  Cy5.5标记的兔抗亲和素

hz-0312R-Bio Rabbit Anti-Avidin/Bio  生物素标记的兔抗亲和素

hz-0312R-AP Rabbit Anti-Avidin/AP  碱性磷酸酶（AP）标记的兔抗亲和素

hz-0312R-HRP Rabbit Anti-Avidin/HRP  辣根过氧化物酶标记的兔抗亲和素

hz-0312R-hzy7 Rabbit Anti-Avidin/Cy7  Cy7标记的兔抗亲和素

hz-0312R-PE Rabbit Anti-Avidin/PE  PE标记的兔抗亲和素

hz-0312R-PE-hzy3 Rabbit Anti-Avidin/PE-Cy3  PE-Cy3标记的兔抗亲和素

hz-0312R-RBIThz Rabbit Anti-Avidin/RBITC  罗丹明标记的兔抗亲和素

hz-0312R-Gold Rabbit Anti-Avidin/Gold  胶体金标记的兔抗亲和素

hz-0312R-FIThz Rabbit Anti-Avidin/FITC  FITC标记的兔抗亲和素

hz-0312R-PE-hzY5 Rabbit Anti-Avidin/PE-CY5  PE-CY5标记的兔抗亲和素

hz-0312R-APhz Rabbit Anti-Avidin/APC  APC标记的兔抗亲和素

hz-0312R-AF350 Rabbit Anti-Avidin/Alexa Fluor 350  Alexa Fluor 350标记的兔抗亲和素

hz-0312R-AF488 Rabbit Anti-Avidin/Alexa Fluor 488  Alexa Fluor 488标记的兔抗亲和素

hz-0312R-AF555 Rabbit Anti-Avidin/Alexa Fluor 555  Alexa Fluor 555标记的兔抗亲和素

hz-0312R-AF647 Rabbit Anti-Avidin/Alexa Fluor 647  Alexa Fluor 647标记的兔抗亲和素

hz-0312R-PE-hzy5.5 Rabbit Anti-Avidin/PE-Cy5.5  PE-Cy5.5标记的兔抗亲和素

hz-0312R-PE-hzy7 Rabbit Anti-Avidin/PE-Cy7  PE-Cy7标记的兔抗亲和素

hz-0311R-hzy3 Rabbit Anti-Biotin/Cy3  Cy3标记的兔抗生物素抗体IgG

hz-0311R-hzy5 Rabbit Anti-Biotin/Cy5  Cy5标记的兔抗生物素抗体IgG

hz-0311R-hzy5.5 Rabbit Anti-Biotin/Cy5.5  Cy5.5标记的兔抗生物素抗体IgG

hz-0311R-hzy7 Rabbit Anti-Biotin/Cy7  Cy7标记的兔抗生物素抗体IgG

hz-0311R-PE Rabbit Anti-Biotin/PE  PE标记的兔抗生物素抗体IgG

hz-0311R-PE-hzy3 Rabbit Anti-Biotin/PE-Cy3  PE-Cy3标记的兔抗生物素抗体IgG

hz-0311R-PE-hzY5 Rabbit Anti-Biotin/PE-CY5  PE-CY5标记的兔抗生物素抗体IgG

hz-0311R-APhz Rabbit Anti-Biotin/APC  APC标记的兔抗生物素抗体IgG