增食欲素/欲激素抗体

英文名称    Pan Orexin    

中文名称    增食欲素/欲激素抗体    

别    名    Hcrt; Hcrt1; Hcrt2; Hypocretin; Hypocretin neuropeptide precursor; Hypocretin-1; Hypocretin-2; OREX_HUMAN; Orexin; Orexin precursor; Orexin-B; OX; PPOX; Contains: Orexin-B; Orexin-A.    

增食欲素/欲激素抗体         

说 明 书    0.1ml  0.2ml      

研究领域    

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    3/3.6kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic mixed peptides derived from human Orexin-B and Orexin-A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

增食欲素/欲激素抗体 产品介绍    background:
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

Subcellular Location:
Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction > synapse. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.

Tissue Specificity:
Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Specific enzymatic cleavages at paired basic residues yield the different active peptides.

DISEASE:
Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1) [MIM:161400]. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.

Similarity:
Belongs to the orexin family.

Gene ID:
3060

Database links:

Entrez Gene: 3060 Human

Omim: 602358 Human

SwissProt: O43612 Human

Unigene: 158348 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

增食欲素/欲激素抗体 

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hz-0310G-PE-hzy5.5 Goat Anti-Chicken IgG/PE-Cy5.5  PE-Cy5.5标记的羊抗鸡IgG

hz-0310G-PE-hzy7 Goat Anti-Chicken IgG/PE-Cy7  PE-Cy7标记的羊抗鸡IgG

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hz-0297G-HRP Goat Anti-human IgG/HRP  辣根过氧化物酶标记的羊抗人IgG

hz-0297G-AP Goat Anti-human IgG/AP  碱性磷酸酶（AP）标记的羊抗人IgG

hz-0297G-PE-hzY5 Goat Anti-human IgG/PE-CY5  PE-CY5标记的羊抗人IgG

hz-0297G-hzy3 Goat Anti-human IgG/Cy3  Cy3标记的羊抗人IgG

hz-0297G-hzy5 Goat Anti-human IgG/Cy5  Cy5标记的羊抗人IgG

hz-0297G-hzy5.5 Goat Anti-human IgG/Cy5.5  Cy5.5标记的羊抗人IgG

hz-0297G-PE-hzy3 Goat Anti-human IgG/PE-Cy3  PE-Cy3标记的羊抗人IgG

hz-0297G-Bio Goat Anti-human IgG/Bio  生物素标记的羊抗人IgG

hz-0297G-APhz Goat Anti-human IgG/APC  APC标记的羊抗人IgG

hz-0297G-AF350 Goat Anti-human IgG/Alexa Fluor 350  Alexa Fluor 350标记的羊抗人IgG

hz-0297G-AF488 Goat Anti-human IgG/Alexa Fluor 488  Alexa Fluor 488标记的羊抗人IgG

hz-0297G-AF555 Goat Anti-human IgG/Alexa Fluor 555  Alexa Fluor 555标记的羊抗人IgG

hz-0297G-AF647 Goat Anti-human IgG/Alexa Fluor 647  Alexa Fluor 647标记的羊抗人IgG

hz-0297G-PE-hzy5.5 Goat Anti-human IgG/PE-Cy5.5  PE-Cy5.5标记的羊抗人IgG

hz-0297G-PE-hzy7 Goat Anti-human IgG/PE-Cy7  PE-Cy7标记的羊抗人IgG

hz-0297G-hzy7 Goat Anti-human IgG/Cy7  Cy7标记的羊抗人IgG

hz-0297G-PE Goat Anti-human IgG/PE  PE标记的羊抗人IgG

hz-0297G-FIThz Goat Anti-human IgG/FITC  FITC标记的羊抗人IgG

hz-0297G-RBIThz Goat Anti-human IgG/RBITC  罗丹明标记的羊抗人IgG

hz-0297G-Gold Goat Anti-human IgG/Gold  胶体金标记的羊抗人IgG

hz-0345G-RBIThz Goat Anti-human IgM/RBITC  罗丹明标记的羊抗人IgM

hz-0345G-FIThz Goat Anti-human IgM/FITC  FITC标记的羊抗人IgM

hz-0345G-hzy3 Goat Anti-human IgM/Cy3  Cy3标记的羊抗人IgM

hz-0345G-hzy5 Goat Anti-human IgM/Cy5  Cy5标记的羊抗人IgM

hz-0345G-hzy5.5 Goat Anti-human IgM/Cy5.5  Cy5.5标记的羊抗人IgM

hz-0345G-hzy7 Goat Anti-human IgM/Cy7  Cy7标记的羊抗人IgM

hz-0345G-PE Goat Anti-human IgM/PE  PE标记的羊抗人IgM

hz-0345G-PE-hzy3 Goat Anti-human IgM/PE-Cy3  PE-Cy3标记的羊抗人IgM

hz-0345G-PE-hzY5 Goat Anti-human IgM/PE-CY5  PE-CY5标记的羊抗人IgM

hz-0345G-APhz Goat Anti-human IgM/APC  APC标记的羊抗人IgM

hz-0345G-AF350 Goat Anti-human IgM/Alexa Fluor 350  Alexa Fluor 350标记的羊抗人IgM

hz-0345G-AF488 Goat Anti-human IgM/Alexa Fluor 488  Alexa Fluor 488标记的羊抗人IgM

hz-0345G-AF555 Goat Anti-human IgM/Alexa Fluor 555  Alexa Fluor 555标记的羊抗人IgM

hz-0345G-AF647 Goat Anti-human IgM/Alexa Fluor 647  Alexa Fluor 647标记的羊抗人IgM

hz-0345G-PE-hzy5.5 Goat Anti-human IgM/PE-Cy5.5  PE-Cy5.5标记的羊抗人IgM

hz-0345G-PE-hzy7 Goat Anti-human IgM/PE-Cy7  PE-Cy7标记的羊抗人IgM

hz-0345G-Bio Goat Anti-human IgM/Bio  生物素标记的羊抗人IgM