黑色素聚集激素/黑色素富集激素MCH抗体

英文名称    PMCH    

中文名称    黑色素聚集激素/黑色素富集激素MCH抗体    

别    名    Melanin concentrating hormone;PMCH; MCH_HUMAN; Pro MCH; Pro melanin concentrating hormone.    

黑色素聚集激素/黑色素富集激素MCH抗体        

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学  信号转导  生长因子和激素      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    16kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PMCH 147-165/165    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

黑色素聚集激素/黑色素富集激素MCH抗体 产品介绍    background:
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Function:
MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus, this effect is antagonized by NEI. In the medial preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior.
NEI can influence differentiation of neuronal processes in brain neurons. Affects the content of neurofilament protein in neuritogenesis (in vitro). May also be a neuromodulatory factor. In behavioral tests, it stimulates exploration and anxiety when injected into the ventromedial nucleus. Also stimulates grooming, locomotion and rearing. May antagonize the inhibitory effect of mch on ACTH release. Reduces dopamine and dopac release in the ventromedial nucleus.

Subcellular Location:
Secreted.

Tissue Specificity:
MCH is present in all regions of the brain and in neurointermediate lobe of the pituarity gland, with highest concentrations in the hypothalamus. Also expressed to a much lesser extent in stomach, lamina propria of both duodenum and colon, ovary, thymus, pancreas, adrenal gland and testis (spermatogonia, early spermatocytes and Sertoli cells). Weak expression in heart and lung. The other peptides are expressed at least in Sertoli cells, nei being also expressed in brain, stomach and proximal duodenum. In brain exclusively mature mch and nei peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. At low levels fully processed MCH and NEI peptides are present in gut. No expression in peripheral blood. 

Post-translational modifications:
Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. 

Similarity:
Belongs to the melanin-concentrating hormone family. 

Gene ID:
5367

Database links:

Entrez Gene: 5367 Human

Entrez Gene: 110312 Mouse

Omim: 176795 Human

SwissProt: P20382 Human

SwissProt: P56942 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

黑色素聚集激素/黑色素富集激素MCH抗体 

hz-0226R Thymosin Alpha-1/PTMA  胸腺肽α1抗体

hz-0706G T4/L-Thyroxine  甲状腺素T4抗体

hz-1300R TIE2/CD202b  血管生成素受体2抗体

hz-3448R Phospho-Tie2 (Ser1119)  磷酸化血管生成素受体2抗体

hz-3449R Phospho-Tie2 (Tyr992)  磷酸化血管生成素受体2抗体

hz-1916R RARRES1/TIG1  视黄酸受体应答蛋白1抗体

hz-1501R Chhzerin/TIG2  视黄酸受体应答蛋白2抗体

hz-1917R Rarres3/TIG3  视黄酸受体应答蛋白3抗体

hz-0640R TIGAR  TIGAR蛋白抗体

hz-0415R TIMP-1(NT)  金属蛋白酶组织抑制因子-1抗体（N端）

hz-0416R TIMP-2  金属蛋白酶组织抑制因子-2抗体

hz-0417R TIMP-3  金属蛋白酶组织抑制因子-3抗体

hz-0418R TIMP-4  金属蛋白酶组织抑制因子-4抗体

hz-3583R TLK1  调节染色体组装激酶1抗体

hz-3424R Phospho-TLK1(Ser695)  磷酸化调节染色体组装激酶1抗体

hz-1919R TLR1  Toll样受体1抗体

hz-1019R TLR2/CD282  Toll样受体2抗体

hz-1444R TLR3  Toll样受体3抗体

hz-1021R TLR4/CD284  Toll样受体4抗体

hz-1197R TLR5  Toll样受体5抗体

hz-2716R TLR6/CD286  Toll样受体6抗体

hz-2717R TLR9/CD289  Toll样受体9抗体

hz-2694R TLR11  Toll样受体11抗体

hz-0525R Thrombomodulin/CD141  血栓调节蛋白抗体

hz-0054R GDNF Receptor alpha 2  胶质细胞系源性神经营养因子受体α2抗体

hz-1327R Tenascin C (C terminal)  细胞粘合素抗体(C端)腱糖蛋白-C(固生蛋白)抗体

hz-1039R Tenascin C/Tn-C  细胞粘合素(固生蛋白)抗体

hz-3849R TMEFF2  增生性息肉蛋白1抗体

hzm-0387M TNF-alpha(1F6)  肿瘤坏死因子-α单克隆抗体

hz-0078R TNF alpha  肿瘤坏死因子-α/TNFα抗体

hz-2081R TNF alpha  肿瘤坏死因子-α/TNFα抗体

hz-2463R TNFSF4/CD252  肿瘤坏死因子配体超家族成员4抗体

hz-2685R TNFRSF4/OX40/CD134  CD134抗体

hz-3851R TNFSF9  肿瘤坏死因子配体超家族成员9抗体

hz-0093R TNF β  肿瘤坏死因子-β抗体

hz-2104R TNFAIP1  肿瘤坏死因子α诱导蛋白1抗体

hz-5725R TNFSF13/CD256/APRIL  肿瘤坏死因子配体超家族成员13抗体

hz-2462R TNFSF14  肿瘤坏死因子配体超家族成员14抗体

hz-5092R TNFSF15/TL1A  肿瘤坏死因子配体超家族成员15抗体

hz-2803R TNFAIP3  肿瘤坏死因子α诱导蛋白3抗体