凋亡诱导受体PLEKHG5抗体

英文名称    PLEKHG5    

中文名称    凋亡诱导受体PLEKHG5抗体    

别    名    PKHG5_HUMAN; Pleckstrin homology domain-containing family G member 5; PH domain-containing family G member 5; Guanine nucleotide exchange factor 720; GEF720.    

凋亡诱导受体PLEKHG5抗体  

说 明 书    0.1ml  0.2ml      

研究领域    染色质和核信号  信号转导  G蛋白偶联受体  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    116kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PLEKHG5    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

凋亡诱导受体PLEKHG5抗体 产品介绍    background:
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Function:
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.

Subunit:
Interacts with GIPC1/synectin and RHOA.

Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Cell projection, lamellipodium. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells.

Tissue Specificity:
Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.

DISEASE:
Distal spinal muscular atrophy, autosomal recessive, 4 (DSMA4) [MIM:611067]: A neuromuscular disorder. Distal spinal muscular atrophy, also known as distal hereditary motor neuronopathy, represents a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. DSMA4 is characterized by childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms and pyramidal signs are absent. Note=The disease is caused by mutations affecting the gene represented in this entry. 
Charcot-Marie-Tooth disease, recessive, intermediate type, C (CMTRIC) [MIM:615376]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Recessive intermediate forms of Charcot-Marie-Tooth disease are characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 DH (DBL-homology) domain. 
Contains 1 PH domain.

Gene ID:
57449

Database links:

Entrez Gene: 57449 Human

Entrez Gene: 269608 Mouse

Entrez Gene: 310999 Rat

Omim: 611101 Human

SwissProt: O94827 Human

SwissProt: Q66T02 Mouse

SwissProt: Q6RFZ7 Rat

Unigene: 284232 Human

Unigene: 332102 Mouse

Unigene: 486442 Mouse

Unigene: 20730 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

凋亡诱导受体PLEKHG5抗体 

hz-5137R TFEB  T淋巴细胞转录调节因子TFEB抗体

hz-1921R TFF2  三叶肽因子2抗体

hz-0535R TFF3  三叶肽因子3抗体

hz-3580R TIF1 Alpha/TRIM24  转录中介因子Tif1α抗体

hz-3581R TIF1 beta/KAP1/TRIM28  转录中介因子Tif1β抗体

hz-3423R Phospho-TIF1 beta(Ser824)  磷酸化转录中介因子Tif1β抗体

hz-3582R TIF1 gamma/Trim33  转录中介因子Tif1γ抗体

hz-2535R TFPI/LACI  组织因子途径抑制剂抗体

hz-1144R TFPI-2  组织因子途径抑制剂-2抗体

hz-0066R TGF alpha  转移生长因子α抗体

hz-0103R TGF Beta 1  转化生长因子β1抗体

hz-4538R TGF Beta 1(CT)  转化生长因子β1抗体

hz-0086R TGFβ1  转化生长因子β1抗体

hz-1838R TIEG1/KLF10  TGF-β诱导早期应答基因1抗体

hz-0100R TGF beta 2 Propeptide  转移生长因子β2抗体

hz-0099R TGF beta 3 propeptide  转移生长因子β3抗体

hz-0638R TGF Beta R1/TGFBR1  转移生长因子β受体1抗体（TGF-βRⅠ）

hz-0117R TGF beta R2/TGFBR2  转移生长因子β受体2抗体（TGF-βRⅡ）

hz-1910R TGF Beta R3  转移生长因子β受体3抗体（TGF-βRⅢ）

hz-1911R TGM3  转谷氨酰酶3抗体

hz-0632R Thioster-containing protein 1  按蚊硫酯包含蛋白-1抗体

hz-1276R ERdj5/DNAJC10  Erdj5/DNAJC10蛋白抗体

hz-1914R thrombin II  凝血酶Ⅱ(凝血因子II)抗体

hz-5476R phospho-MAPK14(Thr180)  磷酸化p38MAPK抗体

hz-1334R TIE1  血管生成素受体1抗体

hz-5477R phospho-MAPK14(Tyr323)  磷酸化p38MAPK抗体

hz-0778R Thy-1/CD90/ Thy1.1  CD90抗体

hz-4137R MAPKAPK5/PRAK  p38调节/激活蛋白激酶抗体

hz-5504R phospho-MAPKAPK5(Thr182)  磷酸化p38调节/激活蛋白激酶抗体

hz-5505R phospho-MAPKAPK5(Ser93)  磷酸化p38调节/激活蛋白激酶抗体

hz-2474R CD93/C1qrp  CD93抗体

hz-2521R CD94/KLRD1  NK细胞表面抑制性受体CD94抗体

hz-2522R CD97  CD97抗体