磷脂酰肌醇3磷酸激酶5Ⅲ型抗体

英文名称    PIP5K3    

中文名称    磷脂酰肌醇3磷酸激酶5Ⅲ型抗体    

别    名    1-phosphatidylinositol-3-phosphate 5-kinase; 1 phosphatidylinositol 3 phosphate 5 kinase; 1 phosphatidylinositol 4 phosphate 5 kinase; CFD; FAB1; FYVE finger containing phosphoinositide kinase; KIAA0981; MGC40423; p235; Phosphatidylinositol 3 phosphate 5 kinase type III; Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III; Phosphatidylinositol 4 phosphate 5 kinase type III; Phosphoinositide kinase, FYVE finger containing; PIKFYVE; PIP5K; PIPkin III; PtdIns(4)P 5 kinase; Type III PIP kinase; ZFYVE29; Zinc finger, FYVE domain containing 29.    

磷脂酰肌醇3磷酸激酶5Ⅲ型抗体      

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  信号转导  激酶和磷酸酶  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PIP5K3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷脂酰肌醇3磷酸激酶5Ⅲ型抗体产品介绍    background:
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.

Subcellular Location:
Endosome membrane

Post-translational modifications:
Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.

DISEASE:
Corneal dystrophy, fleck (CFD) [MIM:121850]: A form of stromal corneal dystrophy characterized by numerous small white flecks scattered in all levels of the stroma, with configurations varying from semicircular to wreath-like, curvilinear, or punctate. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision.

Similarity:
Contains 1 DEP domain.
Contains 1 FYVE-type zinc finger.
Contains 1 PIPK domain. 

Database links:

Entrez Gene: 200576 Human

Omim: 609414 Human

SwissProt: Q9Y2I7 Human

Unigene: 173939 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷脂酰肌醇3磷酸激酶5Ⅲ型抗体

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hz-1136R synaptotagmin-2  突触结合蛋白相关基因2抗体

hz-1897R Synaptotagmin-4  突触结合蛋白4抗体

hz-3972R Synaptotagmin 5  突触结合蛋白5抗体

hz-1898R SPATA12  睾丸特异表达新基因5抗体

hz-1899R SRG11/Spata17  睾丸凋亡基因抗体

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hz-5818R Sulfatase 1  硫酸酯酶1抗体

hz-3857R SSDD/Steroid sulfatase  类固醇硫酸酯酶抗体

hz-3894R Sulfatase 2  硫酸酯酶2蛋白抗体

hz-3575R SSEA3  阶段特异性胚胎表面抗原-3抗体

hz-1381R AKAP12/Gravin  丝氨酸抑制蛋白激酶C底物抗体

hz-1702R CD15/Fut4/SSEA-1  阶段特异性胚胎表面抗原-1抗体

hz-1137R SSTR1  生长抑素受体1抗体

hz-1138R SSTR2  生长抑素受体2抗体

hz-1368R SSTR3  生长抑素受体3抗体

hz-1900R SSTR4  生长抑素受体4抗体

hz-1139R SSTR5  生长抑素受体5抗体

hz-3570R StAR/StARD1  促黄体激素诱导蛋白抗体

hz-3919R STARD5  促黄体激素诱导蛋白5抗体

hz-1317R STAT1  信号转导与转录激活因子1抗体

hz-1657R phospho-STAT1 (Tyr701)  磷酸化信号转导与转录激活因子1抗体

hz-3427R phospho-STAT1 (Ser727)  磷酸化信号转导与转录激活因子1抗体

hz-1140R STAT2  信号转导和转录激活因子2抗体

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hz-5619R phospho-STAT5a(Ser726)  磷酸化信号转导和转录激活因子5a抗体

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