丝氨酸/苏氨酸蛋白磷酸酶PGAM5抗体

英文名称    PGAM5    

中文名称    丝氨酸/苏氨酸蛋白磷酸酶PGAM5抗体    

别    名    Bcl-XL-binding protein v68; BXLBv68; MGC5352; mitochondrial; PGAM5; PGAM5_HUMAN; Phosphoglycerate mutase family member 5; Serine/threonine protein phosphatase PGAM5 mitochondrial; Serine/threonine-protein phosphatase PGAM5.    

 丝氨酸/苏氨酸蛋白磷酸酶PGAM5抗体     

说 明 书    0.2ml      

研究领域    细胞生物  信号转导  激酶和磷酸酶  线粒体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    32kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PGAM5    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 丝氨酸/苏氨酸蛋白磷酸酶PGAM5抗体产品介绍    background:
Members of the PGAM (phosphoglycerate mutase) family of proteins are important components of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism. They are responsible for catalyzing the transfer of phospho groups between the carbon atoms of phosphoglycerates. PGAM5 (phosphoglycerate mutase family member 5), also known as Bcl-xL-binding protein v68, is a 289 amino acid protein belonging to the BPG-dependent PGAM subfamily. PGAM5 exists as two isoforms produced by alternative splicing events, with isoform two localized to the cytoplasm and isoform one localized to both the cytoplasm and the nucleus. PGAM5 forms a dimer and has been found to interact with Bcl-xS/L and Keap1.

Function:
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression.

Subcellular Location:
Mitochondrion. Mitochondrion outer membrane. Membrane. Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.

Similarity:
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Gene ID:
192111

Database links:

Entrez Gene: 192111 Human

Entrez Gene: 72542 Mouse

Entrez Gene: 288731 Rat

SwissProt: Q96HS1 Human

SwissProt: Q8BX10 Mouse

SwissProt: Q562B5 Rat

Unigene: 102558 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 丝氨酸/苏氨酸蛋白磷酸酶PGAM5抗体

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