平足蛋白/淋巴管内皮细胞蛋白抗体

英文名称    Podoplanin    

中文名称    平足蛋白/淋巴管内皮细胞蛋白抗体    

别    名    Podoplanin Protein; AGGRUS; GLYCOPROTEIN 36 KD; Podoplanin; Glycoprotein 36; gp 36; GP 38; GP 40; gp36; GP38; GP40; HT1A 1; HT1A1; hT1alpha1; hT1alpha2; Lung type I cell membrane associated glycoprotein; Lung type I cell membrane associated glycoprotein isoform a; Lung type I cell membrane associated glycoprotein T1A 2; OTS 8; OTS8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; Podoplanin; T1 alpha; T1 ALPHA GENE; T1A; TIA 2; TIA2.    

平足蛋白/淋巴管内皮细胞蛋白抗体 

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  心血管  细胞生物  免疫学  血管内皮细胞  淋巴细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Podoplanin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

平足蛋白/淋巴管内皮细胞蛋白抗体 产品介绍    background:
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.

Tissue Specificity:
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

Post-translational modifications:
Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
The N-terminus is blocked.

Similarity:
Belongs to the podoplanin family.

Gene ID:
14726

Database links:

Entrez Gene: 10630 Human

Entrez Gene: 14726 Mouse

Entrez Gene: 54320 Rat

Omim: 608863 Human

SwissProt: Q86YL7 Human

SwissProt: Q62011 Mouse

SwissProt: Q64294 Rat

Unigene: 468675 Human

Unigene: 2976 Mouse

Unigene: 794 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

平足蛋白/淋巴管内皮细胞蛋白抗体 

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hz-1127R SGCB/SGC  肌聚多糖-β抗体

hz-1128R SGLT1/GLT 1  钠-糖共转运载体1抗体

hz-3395R Phospho-SGK1 (Ser78)  磷酸化糖皮质激素调节激酶1抗体

hz-3396R Phospho-SGK1 (Ser422)  磷酸化糖皮质激素调节激酶1抗体

hz-3397R Phospho-SGK1 (Thr256)  磷酸化糖皮质激素调节激酶1抗体

hz-3858R SH2D2A  血管内皮生长因子受体相关蛋白抗体

hz-0211R SHANK 1  富含脯氨酸突触相关蛋白SHANK1抗体

hz-2149R Shadow/shadow of prion protein  新朊蛋白抗体

hz-4566R Shadow/shadow of prion protein(CT)  新朊蛋白抗体（C端）

hz-1175R SHBG  性激素结合球蛋白抗体

hz-3572R SHC  SH2结构域转化蛋白1抗体

hz-3410R phospho-SHC(Ser36)  磷酸化SH2结构域转化蛋白1抗体

hz-3411R phospho-SHC(Tyr349)  磷酸化SH2结构域转化蛋白1抗体

hz-3412R phospho-SHC (Tyr427)  磷酸化SH2结构域转化蛋白1抗体

hz-3413R phospho-SHC (Tyr317)  磷酸化SH2结构域转化蛋白1抗体

hz-3414R phospho-SHC(Tyr239/240)  磷酸化SH2结构域转化蛋白1抗体

hz-0882R Shiga-like toxin IIe variant subunit A  大肠杆菌志贺样毒素Ⅱ型突变体（O139菌型）抗体

hz-1544R Shh  Shh信号转导通路膜蛋白受体抗体

hz-2699R OMPC  大肠杆菌外膜孔道蛋白C抗体

hz-3567R SHIP1  SH2结构含磷酸肌醇SHIP1抗体

hz-3398R Phospho-SHIP1 (Tyr1020)  磷酸化SH2结构含磷酸肌醇SHIP1抗体

hz-1129R SHP-1  造血细胞磷酸酶抗体

hz-3629R PTPN4/MEG1  蛋白酪氨酸磷酸酶非受体型4抗体

hz-1233R PTPN11  蛋白酪氨酸磷酸酶2抗体

hz-3399R Phospho-INPPL1(Tyr1135)  肌醇聚磷酸盐磷酸酶样蛋白1抗体

hz-3402R Phospho-INPPL1(Ser576)  肌醇聚磷酸盐磷酸酶样蛋白1抗体

hz-3403R Phospho-PTPN11(Tyr542)  磷酸化蛋白酪氨酸磷酸酶2抗体

hz-3404R Phospho-INPPL1(Tyr986/987)  肌醇聚磷酸盐磷酸酶样蛋白1抗体

hz-3405R Phospho-PTPN11 (Tyr584)  磷酸化蛋白酪氨酸磷酸酶2抗体

hz-5434R Phospho-SHP2/SHIP2(Tyr477)  磷酸化蛋白酪氨酸磷酸酶2抗体

hz-5638R Phospho-SHP2/SHIP2(Tyr81)  磷酸化蛋白酪氨酸磷酸酶2抗体

hz-3596R SIAH1  泛素连接酶Siah1抗体

hz-3634R SIAH2  泛素连接酶Siah2