血浆激肽释放酶轻链抗体

英文名称    Plasma kallikrein light chain    

中文名称    血浆激肽释放酶轻链抗体    

别    名    Plasma kallikrein B1; EC 3.4.21.34; Fletcher factor; Kallikrein 3 plasma (Fletcher factor); kallikrein B plasma; Kallikrein B plasma (Fletcher factor) 1; Kallikrein B, plasma 1; Kininogenin; KLK3; KLKB1; KLKB1_HUMAN; Plasma kallikrein; Plasma prekallikrein; PPK; Prekallikrein; Plasma kallikrein light chain.    

血浆激肽释放酶轻链抗体       

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    27kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Plasma kallikrein light chain    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

血浆激肽释放酶轻链抗体产品介绍    background:
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]

Function:
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. 

Subunit:
Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds. 

Subcellular Location:
Secreted.

Post-translational modifications:
Prekallikrein deficiency (PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect. Note=The disease is caused by mutations affecting the gene represented in this entry. 

Similarity:
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. 

Gene ID:
3818

Database links:

Entrez Gene: 3818 Human

Entrez Gene: 25048 Rat

Omim: 229000 Human

SwissProt: P03952 Human

SwissProt: P14272 Rat

Unigene: 237642 Human

Unigene: 9880 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

血浆激肽释放酶轻链抗体

hz-1883R Rbms3  抑癌基因Rbms3抗体

hz-2793R RET/C ret  指状蛋白RET抗体

hz-3384R Phospho-Ret (Tyr905)  磷酸化指状蛋白RET抗体

hz-3385R Phospho-Ret (Tyr1062)  磷酸化指状蛋白RET抗体

hz-0795R Resistin  抵抗素抗体

hz-2214R Resistin  抵抗素抗体

hz-1884R RELMa/RELM alpha  抵抗素样分子α抗体

hz-3562R RelB  核转录因子NFKB-RelB蛋白抗体

hz-3383R Phospho-RelB(Ser552)  磷酸化核转录因子NFKB-RelB蛋白抗体

hz-5692R Phospho-RelB(Ser573)  磷酸化核转录因子NFKB-RelB蛋白抗体

hz-1885R Reprimo  细胞质内的糖基化蛋白抗体

hz-2666R C-REL  淋巴细胞衍生C-型凝集素抗体

hz-0492R RGS2  G蛋白信号转导调节因子2抗体

hz-2794R RGS5  G蛋白信号转导调节因子5抗体

hz-3867R RGS19  G蛋白信号转导调节因子19抗体

hz-5686R phospho-RGS19(Ser22)  磷酸化G蛋白信号转导调节因子19抗体

hz-5687R phospho-RGS19(Ser24)  磷酸化G蛋白信号转导调节因子19抗体

hz-5688R phospho-RGS19(Ser151)  磷酸化G蛋白信号转导调节因子19抗体

hz-5689R phospho-RGS19(Tyr143)  磷酸化G蛋白信号转导调节因子19抗体

hz-1180R RhoA  RhoA抗体

hz-1480R Rho C  RhoC抗体

hz-5949R RNF56/CBLB  环指蛋白56

hz-3546R RIP2  受体结合丝氨酸苏氨酸激酶2抗体

hz-3361R Phospho-RIP2 (Ser176)  磷酸化受体结合丝氨酸苏氨酸激酶2抗体

hz-3551R RIPK3  受体结合丝氨酸苏氨酸激酶3抗体

hz-3564R RICTOR  雷帕霉素靶蛋白复合体2抗体

hz-3387R Phospho-Rictor (Thr1135)  磷酸化雷帕霉素靶蛋白复合体2抗体

hz-2125R RNF126  环指蛋白126抗体

hz-2163R RNF148  环指蛋白148抗体

hz-6096R RNF139  环指蛋白139抗体

hz-4104R FXYD1  磷酸神经膜抗体

hz-1166R ROCK1  Rho相关蛋白激酶1抗体

hz-4630R phospho-ROCK1(Thr455/Ser456)  磷酸化Rho相关蛋白激酶1抗体

hz-1205R ROCK2  Rho相关蛋白激酶2抗体

hz-5674R phospho-ROCK2(Thr396)  磷酸化Rho相关蛋白激酶2抗体

hz-5675R phospho-ROCK2(Thr249)  磷酸化Rho相关蛋白激酶2抗体

hz-5676R phospho-ROCK2(Tyr256)  磷酸化Rho相关蛋白激酶2抗体