磷脂酰肌醇激酶催化亚单位p101抗体

英文名称    PIK3R5    

中文名称    磷脂酰肌醇激酶催化亚单位p101抗体    

别    名    PIK3R5; PIK3 R5; PI 3-kinase p101; PI3K p101; PI3R5_HUMAN; Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K; p101-PI3K; FOAP 2; FOAP2.    

磷脂酰肌醇激酶催化亚单位p101抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  信号转导  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    97kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PIK3R5    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷脂酰肌醇激酶催化亚单位p101抗体 产品介绍    background:
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Function:
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.

Subunit:
Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.

Subcellular Location:
Nucleus. Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity:
Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.

DISEASE:
Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. Note=The disease is caused by mutations affecting the gene represented in this entry.

Gene ID:
23533

Database links:

Entrez Gene: 23533 Human

Entrez Gene: 320207 Mouse

Entrez Gene: 497931 Rat

Omim: 611317 Human

SwissProt: Q8WYR1 Human

SwissProt: Q5SW28 Mouse

Unigene: 278901 Human

Unigene: 738684 Human

Unigene: 244960 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷脂酰肌醇激酶催化亚单位p101抗体 

hz-3676R RALDH2  视黄醛脱氢酶2型抗体

hz-5709R ALDH1L1  乙醛脱氢酶1蛋白家族L1抗体

hz-1731R phospho-c-Raf(Ser338/Tyr340)  磷酸化原癌基因c-Raf抗体

hz-3372R phospho-c-Raf (Ser289)  磷酸化原癌基因c-Raf抗体

hz-3375R phospho-c-Raf(Ser259)  磷酸化原癌基因c-Raf抗体

hz-3376R phospho-c-Raf(Ser296)  磷酸化原癌基因c-Raf抗体

hz-3377R phospho-c-Raf(Ser338)  磷酸化原癌基因c-Raf抗体

hz-5645R phospho-c-Raf(Ser301)  磷酸化原癌基因c-Raf抗体

hz-5646R phospho-c-Raf(Ser462)  磷酸化原癌基因c-Raf抗体

hz-5647R phospho-c-Raf(Ser494)  磷酸化原癌基因c-Raf抗体

hz-5648R phospho-c-Raf(Ser43)  磷酸化原癌基因c-Raf抗体

hz-5649R phospho-c-Raf(Ser471)  磷酸化原癌基因c-Raf抗体

hz-5650R phospho-c-Raf(Tyr341)  磷酸化原癌基因c-Raf抗体

hz-5651R phospho-c-Raf(Thr269)  磷酸化原癌基因c-Raf抗体

hz-3560R RASGRF1  Ras特异性鸟嘌呤核苷酸释放因子1

hz-3382R Phospho-RasGRF1(Ser916)  磷酸化Ras特异性鸟嘌呤核苷酸释放因子1

hz-5652R phospho-c-Raf(Ser339)  磷酸化原癌基因c-Raf抗体

hz-5683R Phospho-RASGRF1(Ser929)  磷酸化Ras特异性鸟嘌呤核苷酸释放因子1

hz-0251R RAR α  维甲酸受体-α 抗体

hz-0516R RAR Beta  维甲酸受体β抗体

hz-6218R RAR gamma/Retinoic Acid Receptor gamma  维甲酸受体γ抗体

hz-1234R RASSF1A  Ras相关区域家族1A抗体

hz-5706R RASSF4  Ras相关区域家族蛋白4抗体

hz-2939R RASSF2  Ras相关结构域蛋白质2抗体

hz-6089R RASSF8  RAS家族关联结构域蛋白8抗体

hz-1515R Pan-ras  Pan ras抗体

hz-3545R RCC1  染色体浓缩调控蛋白1抗体

hz-3360R Phospho-RCC1 (Ser11)  磷酸化染色体浓缩调控蛋白1抗体

hz-3558R phospho-Rb(Ser249)  视网膜母细胞瘤相关蛋白1抗体

hz-3378R Phospho-Rb (Ser608)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-3380R Phospho-Rb (Ser807/Ser811)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-3452R Phospho-Rb (Thr821)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-5653R Phospho-Rb(Ser612)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-5665R Phospho-Rb(Ser788)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-5666R Phospho-Rb(Ser795)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-5667R Phospho-Rb(Thr826)  磷酸化视网膜母细胞瘤相关蛋白1抗体

hz-0645R Rat secretory IgA  分泌型免疫球蛋白A抗体

hz-2901R RECK  金属蛋白酶抑制因子RECK抗体

hz-3691R REG4/RELP  再生基因蛋白4抗体

hz-1560R RELN/Reelin  络丝蛋白抗体