T细胞特异性趋化因子抗体

英文名称    RANTES    

中文名称    T细胞特异性趋化因子抗体    

别    名    RANTES; CCL5; TCP228; Small Inducible Cytokine A5; CCL5; SISd; MGC17164; SCYA5; RANTES; D17S136E; SIS-delta; chemokine (C-C motif) ligand 5; regulated on activation normal T cell expressed and secreted; chemokine (C-C motif) ligand 5; T-cell-specific protein RANTES; C-C motif chemokine 5; EoCP; Eosinophil chemotactic cytokine; RANTES(3-68); RANTES(4-68);    

T细胞特异性趋化因子抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  趋化因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    7.4/10kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CCL5 (62-91aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

T细胞特异性趋化因子抗体 产品介绍    background:
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

Function:
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

Subcellular Location:
Secreted.

Tissue Specificity:
T-cell and macrophage specific.

Post-translational modifications:
N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. 
The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

Gene ID:
6352

Database links:

Entrez Gene: 6352 Human

Omim: 187011 Human

SwissProt: P13501 Human

Unigene: 514821 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

T细胞特异性趋化因子抗体 

hz-3740R phospho-PP1A/PP2CA (Thr320)  磷酸化蛋白磷酸酶2Cα抗体

hz-5422R PP1C gamma  蛋白磷酸酶γ1抗体

hz-0029R PP2A alpha/beta  蛋白质磷酸酶-2A抗体

hz-4162R PP2CA/PPM1A  蛋白磷酸酶2C亚型α抗体

hz-5586R phospho-PPM1A(Ser375)  磷酸化蛋白磷酸酶2C亚型α抗体

hz-0490R PP2Ac/PP4C  磷酸酯酶-2Ac抗体

hz-0250R PPAR-delta/beta  D型-过氧化酶活化增生受体抗体

hz-3614R PPAR alpha  α型-过氧化酶活化增生受体抗体

hz-4055R phospho-PPAR alpha(Ser12)  磷酸化α型-过氧化酶活化增生受体抗体

hz-0530R PPAR gamma  过氧化酶活化增生受体γ抗体

hz-3737R Phospho-PPAR Gamma (ser112)  磷酸化过氧化酶活化增生受体γ抗体

hz-5912R PPIA/Cyclophilin A  亲环蛋白（亲环素）PPIA抗体

hz-5911R PPIB/Cyclophilin B  亲环蛋白（亲环素）PPIB抗体

hz-3536R PPIG  亲环蛋白（亲环素）PPIG抗体

hz-3461R Phospho-PPIG (Ser376)  磷酸化亲环蛋白（亲环素）PPIG抗体

hz-2398R PPIL1  亲环素相关蛋白1抗体

hz-0115R AKT/PKB  蛋白激酶B

hz-0876R phospho-AKT/PKB(Ser473)  磷酸化蛋白激酶B抗体

hz-2720R phospho-Akt(Thr308)  磷酸化蛋白激酶B抗体

hz-5182R phospho-AKT1/AKT2(Thr308+Thr309)  磷酸化蛋白激酶B抗体

hz-5188R phospho-AKT1(Ser129)  磷酸化蛋白激酶B抗体

hz-3043R phospho-Akt(Thr450)  磷酸化蛋白激酶B抗体

hz-3073R Phospho-HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155)  磷酸化组蛋白去乙酰化酶4/5/7抗体

hz-3211R Phospho-HDAC4(Ser632)/HDAC5(Ser498)/HDAC7(Ser486)  磷酸化组蛋白去乙酰化酶4/5/7抗体

hz-4296R hnRNP K  异质核糖核蛋白K抗体

hz-5194R phospho-AKT1(Thr34)  磷酸化蛋白激酶B抗体

hz-5390R Seladin 1/DHCR24  24脱氢胆固醇还原酶抗体

hz-0875R PKN2  蛋白激酶N2抗体

hz-1436R RKIP/PBP  磷脂酰乙醇胺结合蛋白1抗体

hz-1493R EIF2AK2/PKR  蛋白激酶R抗体

hz-3335R Phospho-PKR (Thr446)  磷酸化蛋白激酶R抗体

hz-3336R Phospho-PKR (Thr451)  磷酸化蛋白激酶R抗体

hz-3337R Phospho-PKR (Thr446/451)  磷酸化蛋白激酶R抗体

hz-2056R AKT2  蛋白激酶B2