呼吸道合胞病毒单克隆抗体

英文名称    RSV    

中文名称    呼吸道合胞病毒单克隆抗体    

别    名    Respiratory Syncytial Virus; RSV; GLYC_HRSVA; Major surface glycoprotein G; Attachment glycoprotein G; Membrane-bound glycoprotein; mG.    

呼吸道合胞病毒单克隆抗体   

说 明 书    

研究领域    细菌及病毒      

抗体来源    Mouse    

克隆类型    Monoclonal    

克 隆 号    E2D1    

交叉反应    Respiratory Syncytial Virus    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

细胞定位    细胞膜 细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

呼吸道合胞病毒单克隆抗体  产品介绍    background:
Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children. RSV infection produces a variety of signs and symptoms involving different areas of the respiratory tract, from the nose to the lungs. RSV is a negative sense, enveloped RNA virus. The virion is variable in shape and size with average diameter of between 120 and 300 nm. The 63 kD RSV fusion protein of the RSS 2 strain (subtype A) directs fusion of viral and cellular membranes, results in viral penetration, and can direct fusion of infected cells with adjoining cells, resulting in the formation of syncytia or multi nucleated giant cells. 

Function:
Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. 
Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

Subunit:
Homooligomer. Interacts (via N-terminus) with protein M. Interacts with protein F; this interaction occurs on the surface of infected cells. Interacts with protein SH. Interacts with host CX3CR1; this interaction modulates host immune response.

Subcellular Location:
Virion membrane. Host cell surface. Isoform Secreted glycoprotein G: Secreted.

Post-translational modifications:
May carry 40-80 separate O-linked carbohydrate chains distributed among the 91 serine and threonine residues. 
Palmitoylated.

Similarity:
Belongs to the pneumoviruses glycoprotein G family.

Database links:
UniProtKB/Swiss-Prot: P03423.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

呼吸道合胞病毒单克隆抗体  

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