RRAD抗体

英文名称    RRAD    

中文名称    RRAD抗体    

别    名    RAD; Ras-related associated with diabetes; RAD1; REM3; Cell cycle checkpoint protein Hrad1; Cell cycle checkpoint protein Rad 1 A / B; Cell cycle checkpoint protein RAD1; Checkpoint control protein HRAD1; Checkpoint control protein RAD1; DNA repair exonuclease; DNA repair exonuclease rad1; DNA repair exonuclease rad1 homolog; DNA repair exonuclease REC1; DNA repair protein RAD1; EC 3.1.11.2; Exonuclease homolog RAD1; GTP-binding protein RAD; hRAD 1; hRAD1; MGC77779; RAD 1; RAD; RAD1 homolog (S. pombe); RAD1 homolog; Rad1 like DNA damage checkpoint; Rad1 like DNA damage checkpoint protein; RAD1, S. pombe, homolog of; Ras associated with diabetes; REC 1; REC1; RRAD; RAD_HUMAN.    

RRAD抗体       

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  糖尿病  内分泌病      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    33kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RRAD    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RRAD抗体产品介绍    background:
Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity. 

Function:
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

Subunit:
Interacts with calmodulin preferentially in the inactive, GDP-bound form. Binds CAMKII which is capable of phosphorylating RAD in vitro. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane (By similarity). 

Subcellular Location:
Cell membrane.

Tissue Specificity:
Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.

Similarity:
Belongs to the small GTPase superfamily. RGK family.

Gene ID:
6236

Database links:

Entrez Gene: 6236 Human

Entrez Gene: 56437 Mouse

Entrez Gene: 83521 Rat

Omim: 179503 Human

SwissProt: P55042 Human

SwissProt: O88667 Mouse

SwissProt: P55043 Rat

Unigene: 1027 Human

Unigene: 29467 Mouse

Unigene: 11189 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

RRAD抗体

hz-3354R Phospho-Pin1 (Ser16)  磷酸化肽基脯氨酞顺反异构酶Pinl抗体

hz-4160R PI 3 Kinase p85 beta  磷脂酰肌醇激酶p85β抗体

hz-5582R phospho-PIK3R2(Tyr467)  磷酸化磷脂酰肌醇激酶p85β抗体

hz-0665R PIWIL1/Miwi  piwi样1蛋白抗体

hz-3817R Piwil2/Mili  piwi样2蛋白抗体

hz-5001R PCK1  磷酸烯醇丙酮酸羧激酶抗体

hz-5002R PCK2  磷酸羧化酶2抗体

hz-0520R PKA/PKAcat/PKACB  蛋白激酶A抗体

hz-3725R Phospho-PRKACB(Thr198)  磷酸化蛋白激酶C亚性抗体

hz-2371R PKA C alpha+beta  蛋白激酶C抗体

hz-4024R phospho-PKA beta(Ser338)  磷酸化蛋白激酶Aβ抗体

hz-3964R PKA gamma  蛋白激酶Aγ抗体

hz-3963R PKA R2/PKA IIα  蛋白激酶A受体2α亚基抗体

hz-4022R phospho-PKA R2 (Ser96)  磷酸化蛋白激酶A受体2α亚基抗体

hz-3965R PKA regulatory subunit I beta  蛋白激酶受体相关1β抗体

hz-0115M PKB/AKT-1  蛋白激酶B

hz-3969R PRKAR1  蛋白激酶A调节亚基a1抗体

hz-3643R PLASTIN3/T Plastin  丝束蛋白T Plastin抗体

hz-3807R PLAP/Phospholipase A2 activator protein  磷脂酶A2激活蛋白抗体

hz-3534R PLC beta 3  磷酯酶Cβ3抗体

hz-3340R Phospho-PLC beta3 (Ser537)  磷酸化磷酯酶Cβ3抗体

hz-3341R Phospho-PLC beta3 (Ser1105)  磷酸化磷酯酶Cβ3抗体

hz-0267R PKC beta 1/2  蛋白激酶C beta 1/2抗体

hz-2505R phospho-PRKCZ(Thr500)  磷酸化蛋白激酶C(T500)抗体

hz-2718R phospho-PKC beta 1/2(Thr500)  磷酸化蛋白激酶C β1/β2(Thr500)抗体

hz-3333R Phospho-PKC alpha/beta II (Thr638/641)  磷酸化蛋白激酶C α/β2抗体

hz-3531R PKC alpha  蛋白激酶C α抗体

hz-3532R PLCG 2/PLC gamma 2  磷酯酶Cγ2抗体

hz-3338R Phospho-PLCG2(Tyr1217)  磷酸化磷酯酶Cγ2抗体

hz-3339R Phospho-PLC gamma 2 (Tyr759)  磷酸化磷酯酶Cγ2抗体

hz-3533R PLCG 1/PLC gamma 1  磷酯酶Cγ1抗体

hz-5547R Phospho-PLC gamma 2(Tyr753)  磷酸化磷酯酶Cγ2抗体

hz-3460R Phospho-PLC gamma 1 (Tyr771)  磷酸化磷酯酶Cγ1抗体

hz-3342R Phospho-PLC gamma 1(Ser1248)  磷酸化磷酯酶Cγ1抗体

hz-3343R Phospho-PLC γ1 (Tyr783)  磷酸化磷酯酶Cγ1抗体

hz-5546R Phospho-PLC gamma 1/PLCG1(Tyr775)  磷酸化磷酯酶Cγ1抗体

hz-5560R phospho-PRKCZ(Thr410)  磷酸化蛋白激酶C(T410)抗体

hz-2329R PKC epsilon  蛋白激酶C抗体

hz-3626R PKC-γ/SCA14  蛋白激酶C亚型G抗体

hz-3729R Phospho-PKC gamma (Thr514)  磷酸化蛋白激酶C亚型G抗体