骨保护蛋白配体/破骨细胞分化因子抗体

英文名称    RANKL    

中文名称    骨保护蛋白配体/破骨细胞分化因子抗体    

别    名    OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.    

骨保护蛋白配体/破骨细胞分化因子抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  发育生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    35kDa    

细胞定位    细胞浆 细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human OPGL    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

骨保护蛋白配体/破骨细胞分化因子抗体产品介绍    background:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].

Function:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Location:
Cytoplasm; Secreted and Cell membrane.

Tissue Specificity:
Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Post-translational modifications:
The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17.

DISEASE:
Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.

Similarity:
Belongs to the tumor necrosis factor family.

Gene ID:
8600

Database links:

Entrez Gene: 8600 Human

Entrez Gene: 21943 Mouse

Omim: 602642 Human

SwissProt: O14788 Human

SwissProt: O35235 Mouse

Unigene: 333791 Human

Unigene: 249221 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

骨保护蛋白配体/破骨细胞分化因子抗体

hz-3276R Phospho-MEK6 (Ser202)  磷酸化丝裂原活化蛋白激酶MKK6抗体

hz-5432R phospho-MEK5(Ser137)  磷酸化丝裂原活化蛋白激酶激酶5抗体

hz-1979R MKK7/ERK7  丝裂原活化蛋白激酶MKK7抗体

hz-3277R Phospho-MKK7 (Ser271/Thr275)  磷酸化丝裂原活化蛋白激酶MKK7抗体

hz-0033R P53 protein(wt-p53)  肿瘤抑制基因P53蛋白抗体（野生型P53）

hz-2090R P53(wt-p53)  肿瘤抑制基因抗体（野生型P53）

hzm-2346M P53(wt-p53) (D2F7)  肿瘤抑制基因野生型P53单抗

hz-0913R Mtp53(N235K N239Y)  突变型P53抗体

hz-1650R phospho-P53(Ser392)  磷酸化肿瘤抑制基因P53抗体

hz-2740R p53BP1/53BP1  p53结合蛋白1抗体

hz-3702R phospho-P53(Ser15)  磷酸化肿瘤抑制基因P53抗体

hz-3703R phospho-P53(Ser20)  磷酸化肿瘤抑制基因P53抗体

hz-3704R phospho-P53(Ser315)  磷酸化肿瘤抑制基因P53抗体

hz-3705R phospho-P53(Ser33)  磷酸化肿瘤抑制基因P53抗体

hz-3706R phospho-P53(Ser37)  磷酸化肿瘤抑制基因P53抗体

hz-3707R phospho-P53(Ser46)  磷酸化肿瘤抑制基因P53抗体

hz-3708R phospho-P53(Ser6)  磷酸化肿瘤抑制基因P53抗体

hz-3709R phospho-P53(Ser9)  磷酸化肿瘤抑制基因P53抗体

hz-3710R phospho-P53(Thr18)  磷酸化肿瘤抑制基因P53抗体

hz-3711R phospho-P53(Thr81)  磷酸化肿瘤抑制基因P53抗体

hz-3020R phospho-p53BP1(Ser25/29)  磷酸化p53结合蛋白1抗体

hz-5596R phospho-P53(Thr55)  磷酸化肿瘤抑制基因P53抗体

hz-0942R WIG-1/PAG608  野生型P53诱导基因1抗体

hz-5597R phospho-P53(Ser376)  磷酸化肿瘤抑制基因P53抗体

hzm-0957M WIG-1/PAG608 (3E4)  野生型P53诱导基因1单克隆抗体

hz-1863R p58ipk  p58ipk抗体

hz-0723R P63 protein/P51A  P63 肿瘤抑制基因抗体

hz-3714R Phospho-p63 (Ser395)  磷酸化P63肿瘤抑制基因抗体

hz-3715R Phospho-p63 (Ser455)  磷酸化P63肿瘤抑制基因抗体

hz-3716R Phospho-p63 (Ser160/Ser162)  磷酸化P63肿瘤抑制基因抗体

hz-1346R P73 protein  P73肿瘤抑制基因抗体

hz-3717R Phospho-p73(Tyr99)  磷酸化P73肿瘤抑制基因抗体

hz-1426R RPS6KB1  核糖体S6蛋白激酶抗体

hz-5668R phospho-RPS6KB1(Ser417)  磷酸化核糖体S6蛋白激酶抗体

hz-5669R phospho-RPS6KB1(Thr 412)   磷酸化核糖体S6蛋白激酶抗体

hz-5670R phospho-RPS6KB1(Ser427)  磷酸化核糖体S6蛋白激酶抗体

hz-1656R phospho-P70 S6 Kinase beta (Thr228)  磷酸化核糖体S6蛋白激酶抗体

hz-5671R phospho-RPS6KB1(Ser434)  磷酸化核糖体S6蛋白激酶抗体

hz-5672R phospho-RPS6KB1(Ser421)  磷酸化核糖体S6蛋白激酶抗体

hz-5673R phospho-RPS6KB1(Ser441+Thr444)  磷酸化核糖体S6蛋白激酶抗体

hz-3617R p70 S6 Kinase Beta 2/P70 Beta 2  核糖体S6蛋白激酶β2抗体

hz-3498R Phospho-p70 S6 Kinase Beta 2 (Tyr389)  磷酸化核糖体S6蛋白激酶β2抗体

hz-3499R Phospho-p70 S6 Kinase Beta (Thr228)  磷酸化核糖体S6蛋白激酶β2抗体

hz-3700R Phospho-p70 S6 Kinase Beta (Thr421/Ser424)  磷酸化核糖体S6蛋白激酶β2抗体